Centrally mediated pain after injury to the knee: A study of pain and function after knee fracture

Not Applicable

• Conditions: Prevalence of centrally mediated pain after intraarticular knee trauma; Musculoskeletal Diseases

• Registration Number: ISRCTN12097923
• Lead Sponsor: niversity of Nottingham

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-11
• Last Update Posted: 22 July 2024
• Study Completion: 2028-07-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1.Adult participants who attended Nottingham University Hospitals under the care of orthopaedic trauma and underwent treatment for intraarticular knee injuries from 2015-2023.
2.Must include one or more of the injury groups outlined below and include an intraarticular component as defined in AO Classification (2018) (1):
2.1.Patella fracture
2.2.Tibial plateau fracture
2.3.Distal femur fracture
3.Able to give informed consent.
4.Able to complete required questionnaires.

Exclusion Criteria

1.Aged 17 years or under
2.Concomitant fracture involving another joint
3.Intra articular knee fracture that involves preceding prosthesis or implant.
4.Active malignancy
5.Pregnancy or breast feeding
6.People in custody of the police or incarcerated persons
7.Inability to read or write English.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measured at a single time point:<br>1. Features of centrally mediated pain measured using quantitative sensory testing (conditioned pain modulation, pressure algometry)<br>2. Central Aspects of Pain in the Knee Questionnaire (CAP-Knee)<br>3. Measures of Central sensitisation and neuropathic pain (Central sensitisation inventory (CSI), PainDETECT questionnaires)<br>4. Numerical Rating Scale (NRS)<br>5. Brief pain inventory (BPI)

Secondary Outcome Measures

Name	Time	Method
Measured at a single time point:<br>1. Features of psychological distress measured using Hospital anxiety and depression scale (HADS)<br>2. Knee Function after trauma, measured using the The Knee Injury and Osteoarthritis Outcome Score (KOOS) and EQ-5D-5L<br>