NCT06524583招募中2 期
Interest of Adjuvant Chemotherapy in Patients With CINSARC High-risk Localized Resected Uterine Leiomyosarcoma - Sarcome 15
适应症
干预措施
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- UNICANCER
- 入组人数
- 198
- 试验地点
- 25
- 主要终点
- Relapse-free survival
研究概览
简要总结
Addition of postoperative chemotherapy to prevent or delay recurrence in patients newly diagnosed with localized uterine leiomyosarcoma and who have undergone complete tumor surgery.
详细描述
This is a biological driven study comprising:
- a multicenter, randomized and comparative phase II trial designed to demonstrate whether adding 4 cycles of post-operative chemotherapy improves relapse-free survival as compared with follow-up (standard management) in patients with resected FIGO stage I uterine leiomyosarcoma, considered at high-risk according to CINSARC NanoCind® signature.
- a prospective cohort for patients with resected FIGO stage I uterine leiomyosarcoma, considered at low-risk according to CINSARC NanoCind® signature.
HIGH-RISK (HR) CINSARC patients will be randomized post-operatively between the two arms of treatment, i.e. standard treatment (active post-surgical surveillance) or chemotherapy, with a 1:1 randomization on one factor: morcellation versus no morcellation of uterine tumor.
LOW-RISK (LR) CINSARC patients' data will be prospectively collected
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patient must have a histologically confirmed diagnosis of uterine leiomyosarcoma obtained less than 8 weeks from the surgery
- •Eastern cooperative oncology group (ECOG) performance status (PS) 0 or 1
- •Patient was previously untreated with chemotherapy for a sarcoma, and did not receive anthracyclines and/or trabectedin for another cancer
- •Available Formalin Fixed Paraffin Embedded (FFPE) tumor blocks in sufficient quantity and quality to allow CINSARC NanoCind® qualification (low-risk or high-risk)
- •Age ≥ 18 years and ≤ 75 years
- •FIGO 2018 classification stage I (IA and IB), with complete resection (total hysterectomy and optional bilateral oophorectomy; possible ovarian preservation is feasible in selected cases)
- •No measurable disease, as assessed by the investigator: normal post-operative thoracic, abdominal and pelvic CT-scan or normal MRI of abdomen and pelvis + normal chest CT performed within 4 weeks prior to inclusion or randomization in the study
- •Signed informed consent form prior to any trial specific procedures consistent with international conference on harmonisation - good clinical practice (ICH-GCP) and local legislation
- •Patient must be affiliated to a social security system or in possession of equivalent private health insurance (according to local regulations for participation in clinical trials).
- •Additional inclusion criteria for randomization
- •Inclusion criteria checked at study entry are all still met at the time of randomization
- •High-risk CINSARC signature
- •Patient must have a diagnosis of uterine leiomyosarcoma confirmed by a local sarcoma expert pathologist from RRePS (Sarcoma Pathology Reference Network from NETSARC +) locally or by the study central RRePS expert pathologist.
- •Adequate hematologic organ function:
- •absolute neutrophil count ≥ 1.5 Giga/ L
- •hemoglobin ≥ 9 g/dL
- •platelets ≥ 100 Giga/L
- •Adequate renal function: serum creatinine ≤ 1.5 mg/dL (≤ 132.6 µmol/L) or calculated creatinine clearance ≥60 mL/min (by the Cockcroft and Gault formula)
- •Adequate liver function: total bilirubin ≤ upper limit of normal (ULN), transaminases ≤ 2.5 x ULN, alkaline phosphatases ≤ 1.5 x ULN
- •Adequate cardiac function: cardiac ultrasound and/or isotopic ventriculography, shortening fraction (SF) > 30%, Left Ventricular Ejection Fraction (LVEF) (per ultrasound or scintigraphy) > 50%
- •Creatine phosphokinase (CPK) ≤ 2,5 x ULN
- •Albumin ≥ 25 g/L
- •Signed informed consent form for the randomized phase, consistent with ICH-GCP and local legislation.
排除标准
- •Exclusion criteria:
- •All other histology types of uterine sarcoma (adenosarcoma, endometrial sarcoma, undifferentiated uterine sarcoma)
- •Prior or concurrent malignant disease diagnosed or treated in the last 5 years except for adequately treated in situ carcinoma of the cervix, basal or squamous skin cell carcinoma, or in situ transitional bladder cell carcinoma
- •Planned pelvic post-operative radiation therapy
- •Metastatic or measurable disease on CT-Scan
- •Known hypersensitivity to doxorubicin or trabectedin or to any of the excipients
- •Any contra-indication for the use of doxorubicin and/or trabectedin treatment
- •Participation in another therapeutic trial within the 30 days prior to inclusion in the study
- •Active viral hepatitis B or C or known human immunodeficiency virus (HIV) infection.
- •Prior anticancer therapy, including radiotherapy, endocrine therapy, immunotherapy, chemotherapy (CT) or other investigational agents within the last 4 weeks (6 weeks for nitrosoureas and mitomycin C)
- •Cardiovascular dysfunction:
- •Congestive heart failure (New York Heart Association [NYHA]) ≥ 2)
- •Myocardial infarction <6 months before study
- •Poorly controlled cardiac arrhythmias
- •Uncontrolled hypertension
- •Unstable (angina symptoms at rest) or new-onset angina (begun within the last 3 months)
- •Ongoing infection > Grade 2 according to NCI-CTCAE v5.0
- •Breastfeeding woman
- •Patients unwilling or unable to comply with the medical procedures and follow-up required by the trial because of geographic, familial, social, or psychological reasons
- •Persons deprived of their liberty or under protective custody or guardianship.
- •Additional exclusion criteria for randomization
- •At least one of the exclusion criteria check at study entry is met at the time of randomization
- •Unknown risk for CINSARC signature
- •For patients who require a pathological review by the study central pathologist, failure to obtain a confirmed diagnosis at randomization
- •More than 13 weeks have elapsed since the surgery procedure.
- •Patient receiving phenytoin within 88 hours prior to randomisation and or live attenuated vaccines within 14 days prior to randomisation and or CYP3A4 inhibitors (e.g. oral ketoconazole, fluconazole, ritonavir, clarithromycin or aprepitant) and or strong CYP3A4 inducers (e.g. rifampicin, phenobarbital, St John's wort).
- •Criteria for continuing in the prospective cohort :
- •Patient must have a diagnosis of uterine leiomyosarcoma confirmed by a sarcoma expert pathologist or by the study central pathologist
- •Patients with a low-risk CINSARC signature
研究组 & 干预措施
Arm B
Experimental
Experimental treatment: 4 cycle of Doxorubicine + trabectedin
干预措施: Doxorubicin (Drug)
Arm B
Experimental
Experimental treatment: 4 cycle of Doxorubicine + trabectedin
干预措施: Trabectedin (Drug)
结局指标
主要结局
Relapse-free survival
时间窗: From randomization or enrollment to disease recurrence or death, up to 5 years
The relapse-free survival is defined as the time from the date of randomization assignment (or the date of enrollment for patients in the prospective cohort) to the date of first disease recurrence/relapse (local/regional recurrence and/or distant metastasis) or death from any cause whichever comes first.
次要结局
- Incidence of adverse events(Throughout study completion, up to 5 years)
- Overall survival(From randomization or enrollment to death, up to 5 years)
- Metastases-free survival(From randomization or enrollment to metastases onset or death, up to 5 years)
- Quality of life questionnaire - Core 30 (QLQ-C30)(At baseline, end of treatment (up to week 12), 4 months, 6 months, 1 year and 2 years)
研究者
研究点 (25)
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