A RANDOMIZED CLINICAL TRIAL TO COMPARE NEBULIZED ROPIVACAINE (0.75 percent) WITH NEBULIZED DEXMEDETOMIDINE ON THE HEMODYNAMIC RESPONSE TO INTUBATION IN PATIENTS UNDERGOING GENERAL ANESTHESIA

All patients included in the study will undergo General physical examination, airway assessment and systemic examination will be done and consent will be taken one day prior to the study. Standard monitoring of hemodynamic parameters (blood pressure, pulse rate, saturation, respiration rate) are done in the preoperative room. On the day of surgery patients are divided into 2 groups with 64 patients each. GROUP D received NEBULIZED DEXMEDETOMIDINE (1mcg/kg) with normal saline 5 ml and GROUP R will receive NEBULIZED ROPIVACAINE (0.75%) 5ml.Patients will receive nebulization 15mins prior to the intubation. Patients are connected to the monitors as per as American Society of Anesthesiologist classification (ASA) guidelines and baseline parameters are monitored in the operative room. Patients are induced according to institutional policy and laryngoscopy should not exceed more than 15 seconds. 

The primary aim of the study is to compare the hemodynamic response with nebulized dexmedetomidine and nebulized ropivacaine and accordingly parameters are measured at various time points like - baseline before and after nebulization, before and after tracheal intubation, minutes after tracheal intubation, at the time of skin closure and immediately and 5 minutes after tracheal extubation.

The secondary aim of the study is to compare the hemodynamic parameters at extubation, and to compare the cough response to extubation

and the incidence rate of postoperative sore throat. Any adverse effects in the perioperative period will be managed as per the institutional policy.