Predictive factors for outcome of lumbar epidural steroid injection in low back pai
Recruiting
- Conditions
- low back paininflammatory cytokineepidural steroid injectionPatients aged at least 20 years old with history of low back pain and/or leg pain who fail conservative treatments (including medications, bed rest, activity modification and/or physical therapy).sciatica pain
- Registration Number
- TCTR20210514004
- Lead Sponsor
- Pornpan Chalermkitpanit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
1. Low back pain with/without leg pain
2. Pain score at least 4 out of 10 after conservative treatments (medication, rehabilitation, bed rest)
Exclusion Criteria
1. Previous lumbar spine surgery
2. Compression fracture or trauma
3. Patients with red flags signs (progressive weakness, infection, tumor, bowel/bladder symptoms)
4. Patients diagnosed of systematic inflammatory diseases (rheumatoid arthritis, inflammatory arthritis, ankylosing spondylitis, etc.)
5. Contagious disease (COVID-19 infection)
6. Allergic to medication
7. Diagnosis of depression
8. Taking oral steroid medications
9. History of prior epidural steroid injection in last three months
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Amount of serum cytokines at 2 weeks after epidural steroid injection (ESI) mmol/l,Pain score at 2 weeks after epidural steroid injection (ESI) Visual Analog Score (VAS), 0-10
- Secondary Outcome Measures
Name Time Method duration of pain relief 50% pain relief weeks,incidence of spine surgery at 6 months after ESI weeks,Correlation of severity of MRI and serum cytokine concentration at 2 weeks after ESI ratio