Study of three doses of phenylephrine,a medicine to increase BP, in pregnant patients having high BP disease, and undergoing caesarean delivery
- Conditions
- Health Condition 1: O149- Unspecified pre-eclampsia
- Registration Number
- CTRI/2023/08/055926
- Lead Sponsor
- niversity College of Medical Sciences and Guru Teg Bahadur Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
1. Preeclamptic females with singleton pregnancy undergoing caesarean section under spinal
anaesthesia
2. Preeclampsia diagnosed as BP more than 140 mmHg systolic or 90 mmHg diastolic on two or more occasions at least 4 hrs apart and proteinuria more than 300 mg in 24 hrs or more than 1+ dipstick test; or signs or symptoms of endorgan
involvement in the absence of proteinuria (including persistent epigastric or right
upper quadrant pain, persistent cerebral symptoms, fetal growth restriction,thrombocytopenia or elevated serum liver enzymes)
1. History suggestive of maternal complications other than preeclampsia e.g. chronic
hypertension, other cardiovascular disease, cerebrovascular disease
2. Multiple gestation
3. Known fetal abnormality
4. Patients with absolute or relative contra-indications for spinal anaesthesia
5. Severe fetal distress or other conditions requiring immediate induction of general
anaesthesia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of physician interventions required to maintain systolic blood pressure near baseline valueTimepoint: Till the time of delivery
- Secondary Outcome Measures
Name Time Method 1. Incidence of reactive hypertension, hypotension & bradycardia <br/ ><br>2. Total phenylephrine requirement <br/ ><br>3. Fetal acid-base status <br/ ><br>4. Incidence of fetal acidosis, defined as umbilical artery pH less than 7.20 <br/ ><br>5. Neonatal Apgar scores at 1 and 5 min <br/ ><br>6. Incidence of nausea, vomiting, dizziness or any other maternal complications <br/ ><br>Timepoint: Till the time of delivery