Efficacy of cold snare polypectomy for the patients taking anticoagulants; Prospective, open label, randomized controlled trial.
- Conditions
- on-pedunculated subcentimetric colorectal polyp (adenoma or sessile serrated adenoma/polyp)
- Registration Number
- JPRN-UMIN000022461
- Lead Sponsor
- Team "Madowazu"
- Brief Summary
The incidence of polypectomy-related major bleeding in the HB+HSP and CA+CSP groups was 12.0% (95% CI, 5.0% to 19.1%) and 4.7% (CI, 0.2% to 9.2%), respectively. The intergroup difference for the primary end point was +7.3% (CI, -1.0% to 15.7%), with a 0.4% lower limit of 2-sided 90% CI, demonstrating the noninferiority of CA+CSP. The mean procedure time for each polyp and the hospitalization period were longer in the HB+HSP than in the CA+CSP group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 184
Not provided
1.Previous enrollment to this study. 2.Inflammatory bowel disease, polyposis patient. 3.Polyps larger than 10mm, lesions suspicious for cancer, pedunculate type polyp, or depressed type polyp. 4.Patients taking steroid, anti platelet, multiple anticoaglants. 5.Non-correctable coagulopathy 6.Pregnancy or lactating 7.Psychiatric disorder 8.Active infection 9.Non-correctable hypertention 10.Chronic respiratory failure 11.Undergo artificial dialysis 12.Inappropriate to participate to the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Procedure related immediate and delayed bleeding rate.
- Secondary Outcome Measures
Name Time Method Hematochezia rate (not requiring endoscopic hemostasis), Immediate bleeding rate, Mean procedure time, Mean hospitalization (for subcentimetric polyp, for all polyps), Number of total colonoscopy for clean colon, Adverse event.