Impulsivity and Time Perception

Completed

• Conditions: Cannabis Use

• Registration Number: NCT03162640
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Cannabis smokers having begun prematurely their consumption (before 16 years) present a persistent impulsivity much later after have stopped their consumptions. The literature highlights that the impulsivity promotes the passage towards a compulsive consumption, and the loss of control. To explain this phenomenon, some authors hypothesized that impulsivity would lead the subjects to overestimate the duration of events and to choose immediate rewards than preferred but delayed rewards. This hypothesis questions the role of the temporal anticipation in the impulsive choices. In a first hypothesis, the temporal impulsivity could be an endogenous deficit bound to the reward, and would be responsible for disorders of the temporal anticipation. In this case, the disorders should be observed especially when the subject anticipates a reward. Alternately, a disorder of the temporal anticipation could provoke impulsivity, and in this case, would be present with or without reward. To separate these hypotheses, we propose to test the capacities of temporal anticipation of non-smokers and early smokers of cannabis by means of a behavioral task " Hazard function task ", which allow to measure the capacity of a subject to anticipate the apparition of an event on the basis of a temporal cue. The neuronal correlates will be measured by a recording EEG of the wave ' CNV ' (fix a quota for denial of variation) which reflects the temporal accumulation and the processes of anticipation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2017-05
• Study Start: 2017-05-05
• Study First Submitted: 2017-05-19
• Study First Submitted QC: 2017-05-19
• Study First Posted: 2017-05-22
• Primary Completion: 2020-03-12
• Study Completion: 2020-03-12
• Last Update Submitted: 2023-08-24
• Last Update Posted: 2023-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

• Healthy volunteers Man or woman of age between 18 and 50 years-old
• Absence of consumption of cannabis and tobacco for 1 year and absence of substance use disorder in history
• Matching in age and sex to the group consumers of cannabis
• Early consumers of cannabis (at the beginning of the consumptions before 16 years)
• Man or woman of age between 18 and 50 years old
• Statement of more than three consumptions a day of cannabis for at least one year and consumption of cannabis having begun before the age of 16 years.
• Urinary analysis is positive for the presence of cannabis
• Positive auto-questionnaire CAST: 2 positive answers to CAST questionnaire
• Hospitalized or not

Exclusion Criteria

• Presence or history of a severe and invalidating somatic pathology (neurological, cardiovascular, lung, metabolic, renal, hepatic, gastro-intestinal)

  • History of cranial trauma with loss of consciousness.
  • substance use disorder except the substance tested in the protocol (cannabis).
  • Invalidating sensory disorders in particular visual: glaucoma, any retinal pathology. Visual acuteness 0.8
  • History of general anesthesia in the previous 3 months the study
  • Any evolutionary neurological or psychiatric pathology
  • Subject under guardianship
  • pregnancy
  • Feeding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measure the capacities of the subjects to anticipate the apparition of the target	8 days after inclusion in the study	on the basis of a temporal cue presented before the target, and give the response as quickly as possible after the presentation of a rewarding versus not rewarding target.

Trial Locations

Locations (1)

Les Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg, Alsace, France