Effect of kiwifruit consumption on gastric emptying

Not Applicable

• Conditions: Diabetes; Metabolic disorder; Metabolic and Endocrine - Other metabolic disorders; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12620000401954
• Lead Sponsor: Crown Research Organisation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-03-25
• Last Update Posted: 30 March 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

•Age: Aged between 18 and 40.
•Sex: Male or female.
•Glucose tolerance: No history of diabetes or evidence of glucose intolerance in a preliminary screening test.
•BMI: Volunteers have a body mass index between 18.5 and 24.99 kg/m2
•Health: Healthy as gauged by self-assessment and result on the General Health Questionnaire.
•Agreement: Subject having given written informed consent to comply with the conditions of the trial.

Exclusion Criteria

•Glucose intolerance: Any history of diabetes or evidence of glucose intolerance in a preliminary test (greater than or equal to 6.0mmol/l fasting glucose, International Diabetes Federation recommendation) and HbA1c greater than 40 mmol/mol
•Non-fasting: Having consumed anything apart from water in the twelve hours prior to the test.
•Allergic or intolerant kiwifruit or wheat
•Pregnant or breastfeeding.
•Long term chronic illnesses requiring treatment, such as cancer and cardiovascular disease.
•Gut conditions or drugs effecting gut transit time, such as irritable bowel syndrome, peptic ulcers and laxatives.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gastric emptying as assessed by exhaled breath analysis[Breath samples will be collected by blowing gently into a 10ml Exetainer with a drinking straw and replacing the cap just before the end of exhalation. Breath samples will be collected at baseline (time = zero minutes) and every 15 min postprandially until 3 hours. Breath samples will be analysed using isotope ratio mass spectrometry.];Blood glucose as assessed by finger-prick blood test[Blood glucose testing will be timed from the start of food consumption by finger prick sampling of capillary blood at 15 min intervals in the first hour and then at 30 min intervals until 180 min has elapsed. Samples will be collected at 0 (baseline x 2), 15, 30, 45, 60, 90, 120, 150 and 180 minutes. The blood glucose will be measured immediately using a HemoCue® blood glucose meter]