Safety and Efficacy of Chula High Flow Nasal Cannula
Phase 1
- Conditions
- High flow nasal cannulaCOVID-19Acute respiratory failurePneumoniaPhase 1 Healthy group Phase 2 COVID-19 with respiratory failure
- Registration Number
- TCTR20210825007
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Phase 1: Healthy subjects (N=5)
Phase 2: COVID-19 pneumonia with respiratory failure (PF ratio 150-300 or SpO2 <90-94% while using conventional oxygen therapy) for at least 2 hours or met other criteria to use HFNC (N=10)
Exclusion Criteria
Phase 1: 1. underlying significant cardiopulmonary disease
2. unable to communicate
Phase 2: 1. signs of respiratory failure (RR>40) or use accessory muscles
2. met criteria for intubation including PF ratio<50, unable to protect airway, mental status change, unstable hemodynamic, reduction in glasgow coma scale<10
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Oxygen parameters (phase 1) 2 hrs pulse oximeter, clinical evaluation,Rox index (phase 2) 2 hrs pulse oximeter, clinical evaluation
- Secondary Outcome Measures
Name Time Method Side effects 2 hrs clinical evaluation