Effect of an immune-supportive diet on gut permeability and allergic symptoms in children with peanut and/or nut allergy.

Recruiting

• Conditions: peanut and nut allergy; leaky gut; 10018012; 10001708; 10014982

• Registration Number: NL-OMON56415
• Lead Sponsor: OLVG

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 132

Inclusion Criteria

- Children of 3 - 18 years of age with a positive open or double-blind
placebo-controlled peanut or nut challenge < 24 months to inclusion;
OR
an obvious and objective IgE-mediated allergic reaction following the
consumption of isolated peanut or nut within 1 hours, confirmed by
sensitisation to peanut or nut < 24 months to inclusion;
- Children who are potty trained or house trained;
- Presence of specific IgE to peanut or a nut >=0.35 kU/l or skin prick test >
3 mm to peanut or nut, determined < 24 months prior to
challenge

Exclusion Criteria

- Only mild symptoms in the oral cavity to peanut or nut due to pollen food
syndrome;
- A negative peanut or nut challenge;
- Children who are not potty trained (house trained);
- Gastro-intestinal diseases (e.g. Morbus Crohn, celiac disease, Colitis
Ulcerosa), lactose-intolerance, severe cow's milk allergy
genetic syndromes, infectious/immunology diseases other than atopy, or
diabetes;
- Use of laxantia, such as lactulose;
- Not being able to read or write Dutch

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Changes in small intestine permeability after 4 months of diet<br /><br>intervention as expressed by the Raffinose/Maltitol ratio (R/M ratio) in urine. </p><br>