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临床试验/NCT03467906
NCT03467906进行中(未招募)不适用

Role of Dietary Habits in Efficacy of Bariatric Surgery - Study B

Brigham and Women's Hospital1 个研究点 分布在 1 个国家目标入组 44 人开始时间: 2021年5月25日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
44
试验地点
1
主要终点
Self-rated hunger

研究概览

简要总结

The purpose of the study is to compare dietary habits after bariatric surgery in patients with poor weight loss versus good weight loss outcomes.

详细描述

The obesity epidemic is a major public health concern with a significant economic burden in the USA. Bariatric surgery is the most effective and durable weight loss treatment, with long-term cardiometabolic health benefits. Among different types of bariatric procedures, sleeve gastrectomy (SG) has become the most commonly performed in USA. While SG is expected to result in a 50-60% excess weight loss, inter-individual differences in weight loss are large and approximately 25% of patients can be considered poor weight-loss responders who either do not lose a substantial amount of weight or regain the lost weight afterwards. The mechanisms underlying this clinical variation remain unknown and interventions to improve on these outcomes critically lacking. Of interest, altered daily dietary habits are experienced by a substantial proportion of bariatric surgery candidates, raising the question whether such alterations may contribute to inter-individual differences in weight loss success. Therefore, the purpose of the study is to compare dietary habits after bariatric surgery in patients with different weight loss outcomes.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
22 Years 至 62 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Bariatric surgery (sleeve gastrectomy) patients

排除标准

  • Insulin-dependent diabetes
  • Shift work within the past 1 year
  • Drug or alcohol dependency
  • Bipolar disorder
  • Post traumatic stress disorder (PTSD)

结局指标

主要结局

Self-rated hunger

时间窗: One day of laboratory protocol

Hunger measured from the visual analogue scale (VAS) questionnaire

次要结局

  • Self-rated appetite(One day of laboratory protocol)
  • Appetite-regulating hormones(One day of laboratory protocol)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Frank AJL Scheer, PhD

Professor of Medicine

Brigham and Women's Hospital

研究点 (1)

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