An observational study to evaluate driving competence in Huntington's disease

Completed

• Conditions: Huntington's disease; movement disorder; 10028037

• Registration Number: NL-OMON43584
• Lead Sponsor: Centre for Human Drug Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

All eligible subjects must meet the following inclusion criteria:
- be at least 18 years of age;
- possess a valid Dutch driver's licence;
- driven at least 300 km in the 12 months prior to study entry, to ensure regular driving activity.;Additional inclusion criteria HD manifest subjects
- confirmed CAG expansion of *36 in the HTT gene;
- UHDRS TMS >5.;Additional inclusion criteria for HD premanifest gene carriers
- confirmed CAG expansion of *36 in the HTT gene;
- UHDRS TMS *5, and no diagnosis in any other HD related domain (i.e. cognition or psychiatric).;Additional inclusion criteria for control subjects
- Gene negative for HD or no family history of HD, preferably spouses or relatives of HD subjects.

Exclusion Criteria

All eligible subjects must meet none of the following exclusion criteria:
- Major comorbidities that are unrelated to HD (i.e. isolated psychiatric disorder, other neurological disorder, paralysis, ophthalmic disorder);
- Drug use (i.e. not medication) in the past 3 till 4 weeks prior to the visit day;
- Alcohol abuse (i.e. 3 or more glasses per day);
- Participation in intervention/clinical trials;
- Any other condition that in the opinion of the investigator warrants exclusion of the study.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified