The Chronic Effects of Low-Load Blood Flow Restriction or Standard of Care Resistance Exercise on Muscle and Neuromuscular Function in Patients With Multiple Sclerosis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 20
- Locations
- 2
- Primary Endpoint
- Change in Functional Outcomes- 6min walk
Study Overview
Brief Summary
This research is being done to compare the current standard of care for strength training for patients with Multiple Sclerosis to lightweight resistance training with blood flow restriction.
Detailed Description
The purpose of this study is to compare the effectiveness of the current Multiple Sclerosis standard of care exercise recommendations to low-load resistance training with blood flow restriction on functional outcomes, strength, muscle size, and neuromuscular control in Multiple Sclerosis patients. This study involves completing 2 training sessions per week for 12 weeks as well as pre- and post-training assessment visits for a total of 29 visits over 14 weeks. All visits will be on UCF's campus with a member of the research team.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Masking Description
Participants and Investigators will be aware of treatment groups
Eligibility Criteria
- Ages
- 18 Years to 55 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Females between the ages of 18 to 55
- •Diagnosed with Multiple Sclerosis
- •Expanded Disability Status Score of 0 to 6.5
- •Able to walk 10 meters without assistance
- •Are willing to come in for all 29 testing visits over 14 weeks
Exclusion Criteria
- •No other known cardiovascular, pulmonary, metabolic, muscular, and/or coronary heart disease
- •Multiple Sclerosis relapse in the past 30 days
- •Are not currently undergoing a rehabilitation protocol
- •Are not currently seeking medical care for a chronic condition that could limit exercise capacity other than multiple sclerosis
- •Are not currently pregnant
Outcomes
Primary Outcomes
Change in Functional Outcomes- 6min walk
Time Frame: Day 2, Week 4 and 8, Day 28
determined via changes in 6 minute walk test, measured by how far (in feet) someone can walk in 6 minutes
Change in Functional Outcomes- MFIS
Time Frame: Day 2, Week 4 and 8, Day 28
determined via changes in Modified Fatigue Impact Scale Questionnaire, sum score of answers on the questionnaire
Change in Functional Outcomes- 10meter
Time Frame: Day 2, Week 4 and 8, Day 28
determined via changes in 10 meter walk test, measured by how fast (in minutes and seconds) someone can walk 10 meters
Change in Functional Outcomes- CST
Time Frame: Day 2, Week 4 and 8, Day 28
determined via changes in sit-to-stand test, measured by how quickly someone can stand from a seated position
Change in Functional Outcomes- 30CST
Time Frame: Day 2, Week 4 and 8, Day 28
determined via changes in 30 second sit-to-stand, measured by how many times someone can stand from a seated position in 30 seconds
Secondary Outcomes
- Changes in Strength(Day 3, Week 4 and 8, Day 29)