NCT04839068Unknown不适用
The Impact of COVID -19 Pandemic Stress on Sex Ratio at Birth and Other Pregnancy Outcomes
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 7,000
- 试验地点
- 1
- 主要终点
- The effect of Covid 19 pandemic stress on sex ratio at birth
研究概览
简要总结
This study is aiming to evaluate the effects of the COVID-19 pandemic stress on pregnancy outcomes including the sex ratio at birth.
详细描述
- Coronavirus disease 2019 (COVID-19) is an emerging respiratory disease caused by a single-strand, positive-sense ribonucleic acid (RNA) virus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus (Masters, 2019).
- The sex ratio (ratio of boys to girls) at birth (SRB) is about 1.01-1.05 in most populations (Abdoli, 2020). Various influencing factors affect the SRB, including maternal stress, endocrine disruption, maternal inflammatory responses and maternal nutrition (Lipner et al., 2019).
- These stressful life events consequently influence on maternal immunological and endocrine conditions, and the male fetuses are more vulnerable to be affected by these conditions. It is of interest that male fetus is biologically weaker and more susceptible to prenatal events and diseases than female fetuses. Hence, premature death is higher in boys than girls (Ahrenfeldt et al., 2017).
- The recent pandemic of the coronavirus disease 2019 (COVID-19) has been known to have various impacts on pregnant women (Rasmussen et al., 2020). Placentas of infected mothers show inflammatory, vascular and thrombotic changes (Prochaska et al., 2020). Among the neonates, children and adults (Bjelosevic et al., 2017), higher morbidity and mortality of males than females were reported. It is observed that the incidence of stillbirth was significantly increased during the pandemic period than during the pre pandemic period in London, UK (Khalilet al., 2020).
- The start of appearance of Covid 19 cases in Egypt was in March 2020, with subsequent increase in cases with its peak in May, June and July 2020, with lockdown and social and financial affection with great stress on families
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •All pregnant women attended to the Women health hospital in a period from January 1st 2019 to December 31st 2019 for child birth or miscarriage (either first or second trimesters) or ectopic or molar pregnancies.
- •All pregnant women attended to the Women health hospital in a period from May 1st 2020 to December 31st 2021 for child birth or miscarriage (either first or second trimesters) or ectopic or molar pregnancies management.
排除标准
- •Pregnant women attended to the Women health hospital in a period from April 1st 2020 to December 31st 2021 for child birth or miscarriage (either first or second trimesters) or ectopic or molar pregnancies management who conceived before April 1st 2020
结局指标
主要结局
The effect of Covid 19 pandemic stress on sex ratio at birth
时间窗: one year
次要结局
未报告次要终点
研究者
Reham Ahmed Abdelreheem
Principal investigator
Assiut University
研究点 (1)
Loading locations...
相似试验
进行中（未招募）
不适用
Stress in Pregnancy During the Covid19 Pandemic and Impact on the Newborn NeurodevelopmentCovid19 and PregnancyNCT06362486Fundación Pública Andaluza para la gestión de la Investigación en Sevilla1,000
已完成
不适用
Impact of COVID-19 Infection During PregnancyCovid-19 in PregnancyNCT05139953Menoufia University65
终止
不适用
Impact of COVID-19 Infection During Pregnancy on Newborns and Young ChildrenPregnancyCovid-19NCT04432779Centre Hospitalier Universitaire Saint Pierre1,362
Unknown
不适用
Effect of Covid-19 on Outcomes of PregnancyPregnancy Without Complications Except Getting Covid-19 InfectionNCT04629001Assiut University1,000
已完成
不适用
Impact of COVID-19 on Pregnancy Outcomes: a Systematic ReviewCOVID-19Pregnancy OutcomesMaternal HealthNeonatal HealthNCT06677281Zahedan University of Medical Sciences1