Removal of cytokines during cardiac surgery

Not Applicable

Recruiting

Conditions: Postoperative inflammatory responseOrgan failure

Registration Number: DRKS00007928

Lead Sponsor: niversitätsklinikum Köln

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

Adult patients > 65 years undergoing cardiac surgery with CPB-duration > 90 min
- Written informed consent

Exclusion Criteria

- Age < 65 years
- Missing informed consent
- Planned CPB temperature < 32°C
- Emergency surgery
- Previous renal replacement therapy
- Preexisting kidney disease not requiring RRT (GFR < 30 mL/min)
- Prior kidney transplant
- Application of contrast medium on the day of surgery
- Immunosuppressive therapy or long-term therapy with corticosteroids
- Acute infective endocarditis
- AIDS with a CD4 count of < 200/µL
- Participation in another clinical intervention trial

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction of IL6 by intraoperative haemoadsorption<br>(Time points: baseline, intraoperative, admission on ICU, day 1 and day 2)

Secondary Outcome Measures

Name	Time	Method
- Length of ICU and hospital stay<br>- ICU and hospital mortality<br>- Number of complications (e. g. pneumonia, delirium, organ failure, infections, renal failure)<br>- Incidence of acute kidney injury (according to AKIN criteria)<br>- Duration of RRT<br>- SOFA-score <br>- Kinetics of different blood and urine markers (IL-6, IL-2, IL-8, IL-10, TNF-alpha, C3a, free haemoglobin, haptoglobin, myoglobin, fibrinogen<br>ICG-PDR, syndecan-1, heparan-sulphate and hyaluronan, [TIMP-2]x[IGFBP7])<br>Time points: baseline, intraoperative, admission on ICU, day 1 and day 2<br><br>- haemodynamics<br>(arterial pressure, heart rate, cardiac output, preload, syst. vascular resistance, extravascular lung water, doses of catecholamines) <br>Time points: baseline, intraoperative, admission on ICU, day 1 and day 2)<br><br>- duration of mechanical ventilation, respiratory function