Incidence of esophagitis, peptic ulcers and small intestinal mucosal lesions induced by loxoprofen, etodolac and celecoxib in healthy volunteers: a prospective randomized comparative trial
- Conditions
- SAID induced gastrointestinal mucosal lesions
- Registration Number
- JPRN-UMIN000009475
- Lead Sponsor
- Second Department of Internal Medicine, Osaka Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 33
Not provided
1) Subjects who have active peptic ulcer or gastrointestinal bleeding and need endoscopic treatment immediately 2) Subjects with significant hepatic disease, renal disease, heart disease or respiratory disease 3) Subjects with a history of gastrointestinal surgery other than appendectomy 4) Subjects orally taking or planning to orally take drug other than loxoprofen, etodolac, celecoxib or famotidine 5) Subjects with alcohol or chemical dependencies 6) Subjects with a history of intestinal obstruction, or person with suspected gastrointestinal obstruction on other tests 7)Subjects who cannot agree that surgery may be required if capsule endoscope retained in the body 8) Subjects whom otherwise the investigator determined ineligible as the subject
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The numbers of small intestinal mucosal breaks evaluated by capsule endoscopy
- Secondary Outcome Measures
Name Time Method