CTRI/2025/11/097215尚未招募不适用
Influence of SLC22A1 rs628031 and KCNJ11 rs5219 genetic polymorphisms on poor therapeutic response to metformin and glimepiride combined therapy in Type 2 Diabetes Mellitus (T2DM) patients belonging to South India.
INTRAMURAL RESEARCH FUND COMMITTEE JIPMER1 个研究点 分布在 1 个国家目标入组 240 人开始时间: 2025年11月25日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 240
- 试验地点
- 1
研究概览
简要总结
This is a case-control pharmacogenetic study for evaluating whether SLC22A1 rs628031 and KCNJ11 rs5219 genetic polymorphisms predict poor glycemic response to metformin and glimepiride combined therapy in type 2 diabetes mellitus patients belonging to south India.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 30.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •A) For Cases
- •Patients started on metformin and glimepiride therapy who are on a stable drug regimen for atleast 6 months and reached the maximum tolerated dose and or or required other add-on antidiabetic drug and their Hb1Ac levels more than 7 percent.
- •Patients with type 2 diabetes mellitus of South Indian origin.
- •South Indian origin is defined as patients with a history of three generations living in any of the southern States (Puducherry, Tamil Nadu, Kerala, Karnataka, Andhra Pradesh and Telangana) and speaking the respective local language as their mother tongue.
- •Both male and female gender.
- •Age 30 years and above.
- •B) For Controls
- •Patients who are on a stable drug regimen of metformin, glimepiride for atleast 6 months and their Hb1Ac levels less than or equal to 7 percent.
排除标准
- •A) For Cases
- •Poor adherence to combination therapy ( adherence rate of less than 90 percent will be considered as poor adherence).
- •Patients with a history of clinically proven renal or hepatic impairment.
- •Patients taking cationic medications like cimetidine, furosemide, nifedipine.
- •Pregnancy and lactation.
- •Patients who regularly consume alcohol [more than 4 standard drinks per day(1 standard drink equals to 10g of pure alcohol)].
- •Patients who diagnosed to have type 1 diabetes, maturity-onset diabetes of the young (MODY), and secondary causes due to endocrinopathies, and chronic intake of steroidal drugs.
- •B) For Controls
- •Patients who regularly consume alcohol [more than 4 standard drinks per day (1 standard drink equals to 10g of pure alcohol)
- •Patients who are diagnosed to have type 1 diabetes, maturity-onset diabetes of the young (MODY) and secondary causes due to endocrinopathies, and chronic intake of steroidal drugs.
研究者
Dr R Kesavan
Jawaharlal Institute of Postgraduate Medical Education and Research
研究点 (1)
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