Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery

Not Applicable

Completed

• Conditions: Impacted Third Molar Tooth; Postoperative Pain; Postoperative Edema
• Interventions: Biological: Platelet-Rich Fibrin (PRF); Device: Kinesio Taping; Other: Standard Postoperative Care

• Registration Number: NCT06900894
• Lead Sponsor: Mustafa Kemal University

Brief Summary

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in reducing postoperative pain, edema, and improving recovery following impacted third molar surgery. A prospective, randomized clinical trial was conducted with 44 patients aged 18-35 years. Patients were assigned to three groups: (1) PRF applied locally to the extraction socket, (2) Kinesio Taping applied postoperatively and removed on the third day, and (3) a control group receiving standard postoperative care. Postoperative outcomes were assessed on days 3 and 7, including pain levels, edema, and quality of life. This study aims to evaluate PRF and Kinesio Taping as non-pharmacological adjuncts in oral and maxillofacial surgery.

Detailed Description

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in postoperative management following impacted mandibular third molar surgery. Postoperative complications, such as pain and edema, are commonly observed and may impact patient comfort and recovery. This study aims to evaluate the feasibility of two non-pharmacological approaches-PRF and Kinesio Taping (Elastic Bandaging)-in postoperative care.

A total of 44 patients aged 18-35 years participated in this prospective, randomized clinical trial. Patients were assigned to one of three groups:

PRF Group: Platelet-rich fibrin (PRF) was applied locally into the extraction socket.

Kinesio Taping Group: An elastic bandage was applied postoperatively to the surgical area and removed on the third day.

Control Group: Standard postoperative care was provided with no additional intervention.

Postoperative evaluations were conducted on the 3rd and 7th days. The measured parameters included:

Edema: Measured using anthropometric techniques.

Pain: Assessed with the Numerical Rating Scale (NRS).

Quality of Life: Evaluated using the Oral Health Impact Profile-14 (OHIP-14).

This study aims to assess the feasibility of PRF and Kinesio Taping in postoperative management.

Study Timeline

• Study Start: 2023-10-01
• Primary Completion: 2024-01-10
• Study Completion: 2024-05-21
• Status Verified: 2025-03
• Study First Submitted: 2025-03-17
• Study First Submitted QC: 2025-03-22
• Study First Posted: 2025-03-28
• Last Update Submitted: 2025-03-28
• Last Update Posted: 2025-04-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Ages 18-35 years
• Systemically healthy individuals
• Non-smokers
• No psychological disorders
• Preoperative pain level between 0-3 on the Numerical Rating Scale (NRS)
• No preoperative edema in the surgical area
• Impacted mandibular third molars classified as Class 1 or 2, Level B, and mesioangular according to the Pell-Gregory classification
• Signed an informed consent form

Exclusion Criteria

• Under 18 or over 35 years old
• Presence of chronic or systemic diseases
• Pregnant or breastfeeding patients
• Surgical duration exceeding 45 minutes
• Smokers
• Patients requiring prophylactic antibiotics due to systemic health conditions
• Patients who did not meet the study criteria or did not sign the informed consent form

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
PRF Group	Platelet-Rich Fibrin (PRF)	Participants in this group received Platelet-Rich Fibrin (PRF) applied to the extraction socket following impacted third molar surgery. PRF was prepared using a centrifugation protocol and placed into the surgical site.
Kinesio Taping Group	Kinesio Taping	Participants in this group received Kinesio Taping applied postoperatively. The elastic therapeutic tape was applied to the masseter and submandibular region following a standardized taping protocol.
Control Group	Standard Postoperative Care	Participants in this group received standard postoperative care, including routine pain management and wound care, without additional interventions.

Primary Outcome Measures

Name	Time	Method
Postoperative Facial Swelling Assessment	Preoperative day 1, postoperative days 3 and 7	Swelling will be evaluated using anthropometric measurement techniques on preoperative (surgery day), postoperative days 1, 3, and 7.; Measurement methods: Lateral canthus-gonion distance (distance from the outer corner of the eye to the mandibular angle) Commissure-tragus distance (distance from the oral commissure to the midpoint of the tragus) All measurements were performed using a flexible ruler, and the results were recorded in millimeters.
Oral Health Impact Profile-14 (OHIP-14) Score	Postoperative days 3 and 7	The quality of life of the patients will be assessed using the OHIP-14 questionnaire on postoperative days 3 and 7.; OHIP-14 consists of 14 standardized items, each rated on a scale from 0 to 4. Total scores range from 0 to 56, with higher scores indicating worse quality of life.; This scale was used to evaluate the impact of postoperative complications on patients' quality of life.
Postoperative Pain Assessment (NRS)	Preoperative day 1, postoperative days 3 and 7	The pain intensity of the patients will be assessed using the Numerical Rating Scale (NRS) on preoperative day 1 and postoperative days 3 and 7.; On this scale: 0 indicates no pain, 10 indicates the worst imaginable pain. Before the procedure, patients were informed about the scale and instructed to rate their pain intensity accordingly.

Trial Locations

Locations (1)

Hatay Mustafa Kemal University, Faculty of Dentistry; 🇹🇷 Hatay, Turkey