Study on pharmacokinetics of prophylactic antibiotics for surgical site infection by ESBL-producing Escherichia coli after lower gastrointestinal surgery
- Conditions
- lower gastrointestinal disease with surgical indication (regardless of benign or malignant)lower gastrointestinal infection, intra-abdominal infection
- Registration Number
- JPRN-jRCTs061190025
- Lead Sponsor
- Ohge Hiroki
- Brief Summary
This study has provided a foothold for clarifying the mechanism of postoperative infection caused by ESBL-producing E. coli, and has also clarified the tissue migration and concentration maintenance of each antimicrobial agent, such as the tendency of CTLZ and TAZ to maintain high concentrations in the peritoneum. We believe that the results of this study will contribute to the prevention of postoperative complications by selecting the optimal antimicrobial agent according to surgical invasion and time requ
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 29
1 Patients scheduled for elective lower gastrointestinal surgery (regardless of open surgery or laparoscopic surgery)
gastrointestinal surgery (limited to open surgery cases)
2 Inpatients over 20 years old (include 20 years old) who agree to participate in this study, regardless of gender
3 Patients who can give written informed consent to participate in this study
1 Patients with a history of allergies to Cefmetazole, Flomoxef, Ceftolozane/Tazobactam or Metronidazole
2 Patients with a history of allergies to cephems
3 Combined use of
4 Patients who are pregnant or nursing
5 Patients with organic diseases in the brain and spinal cord
6 Patients with renal dysfunction who have creatinine clearance less than 50 ml / min estimated by Cockloft-Gault equation
7 Patients judged inappropriate for this study by the researcher
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method