Effect of subgingival instrumentation on neutrophil elastase and C-reactive protein in grade B and C periodontitis: exploratory analysis of a cohort study
Not Applicable
- Conditions
- periodontitis
- Registration Number
- DRKS00026952
- Lead Sponsor
- Poliklinik für Parodontologie,ZZMK (Carolinum) der Johann Wolfgang Goethe-Universität Frankfurt a.M.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
= 16 years of age
- = 20 remaining teeth
- written informed consent
Exclusion Criteria
- Patients that may require preventive use of systemic antibiotics for measurements that may cause transitory bacteraemia (e.g. pocket probing)
- Self-reported chronic disease influencing the serum CRP level (e.g. Rheumatoid Arthritis, Crohn’s Disease or Ulcerative Colitis)
- Self-reported infectious disease within the last 8 weeks before examination (history of fever)
- Any clinically assessed chronic dermal or mucosal inflammatory condition (e.g. lichen planus)
- Nonsurgical or surgical periodontal treatment within the last 24 months before examination
- Systemic or topical subgingival antibiotics within the last 8 weeks before examination
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method serum level of neutrophil elastase and CRP; blood sampling prior to non-surgical periodontal treatment (subgingival instrumentation), 1 day, 6 weeks, and 3 months thereafter
- Secondary Outcome Measures
Name Time Method leukocyte number, serum level of IL-6, IL-8 and LBP; blood sampling prior to non-surgical periodontal treatment (subgingival instrumentation), 1 day, 6 weeks, and 3 months thereafter