Myocardial Oedema in ST Segment Elevation Myocardial Infarction Myocardial
- Conditions
- ST Segment Elevation Myocardial InfarctionMyocardial Oedema
- Interventions
- Other: Cardiac magnetic resonance imaging
- Registration Number
- NCT01897350
- Lead Sponsor
- Elisa McAlindon
- Brief Summary
Cardiac magnetic resonance imaging (CMR) is a non invasive technique used to obtain functional and anatomical information on the heart. Several CMR parameters measured after primary percutaneous coronary intervention (PPCI) have been shown to have prognostic value and are increasingly being used as surrogate endpoints in clinical trials. Myocardial oedema is a prognostic indicator following myocardial infarction1. Myocardial salvage is calculated as the myocardial oedema minus infarct size; this again is a prognostic indicator following STEMI. However, myocardial oedema imaging is controversial. There are multiple sequences available, with no standardisation of sequences used to assess this surrogate endpoint. The investigators propose to conduct a study to measure the myocardial oedema by all available techniques to determine the agreement between these methods.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- STEMI
- providing written informed consent
- contraindication to CMR,
- atrial fibrillation,
- claustrophobia,
- eGFR < 30
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description CMR following ST segment myocardial infarction Cardiac magnetic resonance imaging -
- Primary Outcome Measures
Name Time Method The mass of myocardial oedema measured by CMR Day 2 following STEMI
- Secondary Outcome Measures
Name Time Method Extra cellular volume Day 2 following STEMI
Trial Locations
- Locations (1)
Bristol Heart Institute
🇬🇧Bristol, Avon, United Kingdom