Tranexamic acid to prevent heavy bleeding after childbirth in women at higher risk

Phase 3

• Conditions: Pregnancy and Childbirth

• Registration Number: PACTR202305473136570
• Lead Sponsor: ondon School of Hygiene and Tropical Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-05-11
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: 30000

Inclusion Criteria

1. Women thought to be aged 18 years or over admitted to hospital for a vaginal or caesarean birth
2. One or more risk factors for PPH including but not limited to:
a) Maternal age = 35 years
b) Grand multiparity (at least 5 previous births)
c) Multiple pregnancies
d) Planned caesarean section
e) Preterm birth
f) Previous PPH
g) Hypertensive disease
h) Abnormal placental implantation
i) Antepartum haemorrhage or placental abruption present
j) Moderate or severe anaemia
k) Other risk factors

Exclusion Criteria

1. Tranexamic acid is clearly indicated (e.g. tranexamic acid has been given within 12 hours or planned to be given)
2. Tranexamic acid is clearly contraindicated (e.g. known allergy to tranexamic acid)

Study & Design

• Study Type: Interventional
• Study Design: Not specified