Evaluation and comparison of the effects of antibiotics loaded A-PRF placed in extraction sockets on bone formation, implant stability and insertion torque in early implant placement at 8 Weeks - A Randomized Controlled Trial

This study is a randomized,parallel group, multiple arm study, comparing the safety and efficacy of  amoxicillin/clavulanic acid and clindamycin as an agents in  local  drug delivery evaluating soft and hard tissue healing ,this study contains one control and two experimental groups, comparing 0.5 ml of amoxicillin/clavulanic acid(1.2)gm  in experimental group one and 0.5 ml of clindamycin(600mg/4 ml) in experimental group two, loaded into the A-PRF as local drug delivery placed into the extraction sockets without any postoperative antibiotics compared with control group where A-PRF alone is  placed in the extraction sockets with post operative antibiotics prescribed. Primary out come is bone healing assessment (histomorphometric analysis) by bone coring at the time of dental implant placement ,secondary outcomes are insertion torqe at the time of implant placement, implant stability at 0,1and 3 months compared in both experimental and control groups.