Evaluation of Novel Lung Function Parameters in Patients With Bronchial Asthma

Completed

• Conditions: Pulmonary Healthy Controls; Bronchial Asthma

• Registration Number: NCT03820427
• Lead Sponsor: Universitätsmedizin Mannheim

Brief Summary

Current guideline-based criteria defining bronchial asthma do not always meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used functional diagnostic approaches for the detection and therapeutic monitoring of patients with asthma.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-08
• Primary Completion: 2018-12
• Study Completion: 2018-12
• Status Verified: 2019-01
• Study First Submitted: 2019-01-22
• Study First Submitted QC: 2019-01-27
• Last Update Submitted: 2019-01-27
• Study First Posted: 2019-01-29
• Last Update Posted: 2019-01-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 147

Inclusion Criteria

• known or suspected bronchial asthma
• known or suspected obstructive ventilation disorder
• pulmonary healthy controls

Exclusion Criteria

• pregnancy
• inability to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Global ventilation heterogeneity	30 minutes	lung clearance index (LCI) derived from sulphur hexafluoride multiple breath washout
Local ventilation heterogeneity	30 minutes	Sacin, Scond (Phase III slopes) derived from sulphur hexafluoride multiple breath washout