Split-Side Comparative Clinical Study of Platelet-Rich Fibrin Versus Platelet-Rich Plasma With or Without Microneedling in Treatment of Striae Distensae
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Zagazig University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- INA score (Change in striae severity)
Overview
Brief Summary
A split-side comparative clinical study evaluating the efficacy and safety of injectable platelet-rich fibrin (PRF) versus platelet-rich plasma (PRP), alone or combined with microneedling, in the treatment of striae distensae. Thirty patients received PRF or PRP on one side and combination therapy with microneedling on the contralateral side over five sessions. Outcomes included striae width, length, severity score, and patient satisfaction
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Adults ≥18 years Presence of striae distensae (rubrae or alba) Willingness to participate and provide informed consent
Exclusion Criteria
- •Keloid or hypertrophic scar tendency Bleeding disorders or anticoagulant use Pregnancy Active skin infections (e.g., herpes, impetigo, tinea) History of malignancy or collagen disease Use of antineoplastic drugs Conditions impairing wound healing Unrealistic expectations
Arms & Interventions
PRF
Intradermal injection of platelet-rich fibrin
Intervention: PRF group (Biological)
PRF +Microneedling
Microneedling followed by topical PRF application
Intervention: PRF+ microneedling (Device)
PRP
Intradermal injection of platelet-rich plasma
Intervention: PRP injection (Biological)
PRP+microneedling
Intervention: PRP +microneedling (Device)
Outcomes
Primary Outcomes
INA score (Change in striae severity)
Time Frame: baseline to 1 month after last session
Change in striae severity (INA score)
Time Frame: 1 month after last session
Secondary Outcomes
No secondary outcomes reported
Investigators
Mona El Radi Kamal Mohamed Emam
Dr
Zagazig University