Study of stress response between two commonly used Techniques of anaesthesia in Less Invasive Spine Surgery
Not Applicable
- Conditions
- Health Condition 1: M472- Other spondylosis with radiculopathy
- Registration Number
- CTRI/2023/07/055471
- Lead Sponsor
- Roshika Gopalakrishnan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Age between 18 and 65 years old of either gender.
2. American society of Anaesthesiologists physical status (ASA) 1 & 2 patients
3. Patients undergoing elective minimally invasive lumbar spine surgery with estimated
duration of 2-4 hours.
Exclusion Criteria
1. Refusal to consent for proposed study.
2. Conversion of minimally invasive spine surgery to open spine surgery
3. Benzodiazepine, Opioids, Corticosteroids, β-blocker, Calcium Channel Blockers, gabapentinoids use within 48 hours.
4. Hypersensitivity to any of the study drugs
5. Chronic or Acute Inflammatory conditions.
6. Endocrine / Hepatic / renal / cardiovascular diseases
7. Pregnant or lactating mothers, malignancy
8. BMI > 30kg/m2
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the surgical stress response in terms of cortisol, glucose, lactate & total leucocyte levels between Total Intravenous Anaesthesia & Balanced Anaesthesia in patients undergoing minimally invasive lumbar spine surgery <br/ ><br>Timepoint: 1.Baseline sampling for cortisol, glucose, lactate, total leucocyte count will be done at the time of drawing blood for routine preoperative investigations 1 day prior to surgery.. <br/ ><br>2.Blood sampling for the assessment of cortisol , glucose, lactate, total leucocyte count will be done postoperatively 2 hours after the surgery
- Secondary Outcome Measures
Name Time Method To analyze the incidence of Post operative nausea & vomiting <br/ ><br>between the groups.Timepoint: From extubation till 2 hours post surgery;To compare the intraoperative fentanyl usage between the two groups.Timepoint: From induction of anaesthesia till extubation;To compare the intraoperative hemodynamic variables between the two groups. <br/ ><br> <br/ ><br>Timepoint: Hemodynamic parameters (Heart rate, Systolic & diastolic blood pressure, mean arterial pressure, oxygen saturation, EtCO2) will be monitored at baseline, post induction, post intubation every 5 mins for the first half an hour, every 15 minutes till the end of procedure and 5 mins post extubation.