Taste Acuity and Caloric Intake After Acute Morphine Administration

Not Applicable

Completed

• Conditions: Feeding Behavior; Taste Sweet; Taste Salty
• Interventions: Behavioral: taste acuity assessment; Behavioral: Recorded meal

• Registration Number: NCT01763697
• Lead Sponsor: Johns Hopkins University

Brief Summary

This study will investigate the effects of acute morphine administration on taste acuity and how much a person eats. It is hypothesized that there will be a dose dependent decrease in taste acuity and dose dependent increase in food intake associated with acute morphine administration. Knowledge from this study will impact the future of feeding behavior and obesity research in the general population. Results will also promote exploration of the long-term effect of opioid abuse on taste acuity and feeding behavior in substance abusing populations.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-01-07
• Study First Submitted QC: 2013-01-07
• Study First Posted: 2013-01-09
• Study Start: 2013-03
• Status Verified: 2014-05
• Primary Completion: 2014-05
• Study Completion: 2014-05
• Last Update Submitted: 2014-05-28
• Last Update Posted: 2014-05-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Healthy adult male and female volunteers
• Ages of 18 to 65

Exclusion Criteria

• History of drug dependence (including opioid use disorders)
• History of taste dysfunction
• Significant medical or Axis I psychiatric disorder
• Any trauma or surgical procedures to the head or neck region
• Medication or illicit drug more than 4 out of the last 30 days.
• Pregnancy
• Abnormal electrocardiogram findings
• Negative rating of greater than 40% of the foods available for consumption

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Morhpine/Taste acuity	taste acuity assessment	Taste acuity assessment after 1mg subcutaneous morphine injection
Morhpine/Taste acuity	Recorded meal	Taste acuity assessment after 1mg subcutaneous morphine injection
Placebo/Taste acuity	taste acuity assessment	Taste acuity assessment after subcutaneous placebo injection
Placebo/Taste acuity	Recorded meal	Taste acuity assessment after subcutaneous placebo injection
Morphine4/Taste acuity	taste acuity assessment	Taste acuity assessment after 4mg subcutaneous morphine injection
Morphine4/Taste acuity	Recorded meal	Taste acuity assessment after 4mg subcutaneous morphine injection

Primary Outcome Measures

Name	Time	Method
Taste	3 hours after dose administration	The primary outcome variable will be the taste acuity profile, which includes the taste detection threshold, recognition threshold, magnitude estimation, and hedonic response.

Secondary Outcome Measures

Name	Time	Method
Calories	6 hours after dose administration	The secondary outcome measure will be the amount of calories consumed over a 2 hours period following the drug administration.

Trial Locations

Locations (1)

Johns Hopkins Bayview Medical Center; 🇺🇸 Baltimore, Maryland, United States