Improvement in Glycemic Response After Bariatric Surgery

Recruiting

• Conditions: Bariatric Surgery
• Interventions: Procedure: sleeve gastrectomy surgery; Procedure: gastric bypass surgery; Procedure: control

• Registration Number: NCT05325736
• Lead Sponsor: Weizmann Institute of Science

Brief Summary

decipher the role of microbiota in glycemic response change after bariatric surgery

Detailed Description

Despite the vast knowledge linking the gut microbiome to metabolism and the glucose response, the relation still remains unclear. hopefully, a deep understanding of the mechanisms underlying metabolic improvement following bariatric surgery will make it possible to identify targets for pharmacological intervention, which will reduce the need for surgery and its risks.

Previous studies have characterized the microbiome after bariatric surgery, but most suffer from methodological limitations.

The current study has the potential to be innovative and make a significant contribution to understanding the mechanisms involved in early metabolic improvement after bariatric surgery.

Study Timeline

• Study Start: 2021-07-01
• Study First Submitted: 2022-02-10
• Study First Submitted QC: 2022-04-05
• Study First Posted: 2022-04-13
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-23
• Last Update Posted: 2025-03-26
• Primary Completion: 2026-07-01
• Study Completion: 2026-07-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• candidates of bariatric surgery or cholecystectomy
• age 18-70
• male/female

Exclusion Criteria

• previous bariatric surgery
• type 1 diabetes
• antibiotic treatment 3 months prior to the study
• probiotic treatment 3 months prior to the study
• chronic disease - gastrointestinal disease, malignancy, psychiatric disorder, endocrinologic disorders
• any pathologic findings during endoscopy
• participants who will suffer from a post-operation complication

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
sleeve gastrectomy surgery	sleeve gastrectomy surgery	participants undergoing sleeve gastrectomy surgery for weight reduction
gastric bypass surgery	gastric bypass surgery	participants undergoing gastric bypass surgery for weight reduction
cholecystectomy	control	participants undergoing cholecystectomy

Primary Outcome Measures

Name	Time	Method
microbiota composition	up to 4 years	The microbiota composition will be assessed using the stool samples of the participants.
Glycemic response	up to 4 years	The glycemic response will be measured by taking a blood test (glucose) after 12 hours fast and a second blood test (glucose) after an OGTT(oral glucose tolerance test) of 50 g glucose

Trial Locations

Locations (2)

Souraski medical center; 🇮🇱 Tel Aviv, Israel

Weizmann Institute of Science; 🇮🇱 Reẖovot, Israel