Comparison of the efficacy of electroconvulsive therapy and repetitive transcranial magnetic stimulationon Major depressive disorder

Phase 1

• Conditions: Condition 1: major depressive Disorder. Condition 2: Recurrent depressive disorder.; Depressive episode; Recurrent depressive disorder

• Registration Number: IRCT138902253930N1
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

INTRODUCTION: <br /> <br /> Studies comparing the antidepressant effects of electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS) have reported mixed results. This study compared the efficacy of rTMS and ECT in adult patients with refractory major depressive disorder (MDD).<br /> <br /> METHODS: <br /> <br /> This randomized, ECT-controlled, parallel-group clinical trial analyzed the antidepressant effects of ECT and rTMS in 73 patients with MDD diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria. The Beck Depression Inventory and Hamilton Depression Rating Scale were used to measure depression.<br /> <br /> RESULTS: <br /> <br /> Both ECT and rTMS significantly improved depression and suicidal behavior scores. However, ECT reduced depression and suicidal behavior scores more than rTMS. There were no significant adverse effects in the rTMS group.<br /> <br /> DISCUSSION: <br /> <br /> Both ECT and rTMS improved MDD in the short term, but the antidepressant efficacy of ECT was greater than rTMS. Moreover, ECT led to greater reductions in suicidal behavior than rTMS. Until strong evidence for the safety and efficacy of rTMS is available, further studies are needed to compare ECT and rTMS in terms of the long-term relapse rate and quality of life.<br />

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Inclusion: 1- major depressive disorder, 2- age>20, 3- voluntary participation.
Exclusion: 1-bipolar mood disorder, 2- serious medical conditions, 3- suicidal attempt, 4- lack of consent.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression score. Timepoint: before and after 10 sessions of intervention. Method of measurement: Questionnaire.