Cardiovascular dose-response to supplemental oxygen in healthy volunteers

Completed

• Conditions: Cardiovasculaire functie; Hyperoxia

• Registration Number: NL-OMON43247
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-05-18
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 23

Inclusion Criteria

18-55 years of age

Exclusion Criteria

- Diagnosed lung pathology (which requires medication or impedes exercise)
- Diagnosed left-right shunt
- Diagnosed cardiovascular disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the change in perfused vessel density (PVD) of<br /><br>small vessels (<20 µm), as measured by sublingual sidestream darkfield imaging. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Hemodynamics, as measured by Nexfin® finger-cuff<br /><br>- Heart Rate<br /><br>- Mean Arterial Pressure<br /><br>- Cardiac Output<br /><br>- Systemic Vascular Resistance<br /><br><br /><br>Perfusion Index measured by pulse-oximetry<br /><br><br /><br>Plasma nitrate levels as an approximation of Nitric Oxide availability.<br /><br><br /><br>Bioelectrical impedance analysis<br /><br>- Reactance<br /><br>- Resistance<br /><br>- Phase angle</p><br>