Intravascular blood volume calculated fluid therapy versus standard fluid therapy in acute pancreatitis
Not Applicable
- Conditions
- Health Condition 1: K85- Acute pancreatitisHealth Condition 2: null- Patients with predicted severe acute pancreatitis within 3 days of onset of illness
- Registration Number
- CTRI/2017/12/010868
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.All consecutive patients with predicted severe acute pancreatitis diagnosed as per revised Atlanta criteria will be included in the study.
2.Hospitalisation within 72 hours of onset of acute pancreatitis
Exclusion Criteria
1.Age < 18 years or > 60 years
2.Patients with Grade 3 / Grade 4 organ failure (as defined by modified marshall classification at enrolment).
3.Patients with underlying co-morbid cardiac, renal, hepatic disease or malignancy.
4.Patients admitted after 72 hours of onset of acute pancreatitis.
5.Pregnancy
6.Refusal to provide consent to participate in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Composite outcome meeting (2 out of the 4 ) adequate perfusion goals : <br/ ><br>SBP more than 100 mm Hg or 40 mm rise from baseline <br/ ><br>Pulse less than 100 beats per min <br/ ><br>Urine output more than 0.5 ml per kg per hr <br/ ><br>Lactate to normal values within 24 hours of resuscitation. <br/ ><br>Co-primary outcome will be measured by improvement in SIRS. <br/ ><br>Secondary outcome will be measured by improvement of organ failure at 72 hours and after 7 days of onset of AP and the difference in the adverse events between the groups <br/ ><br>Timepoint: from illness onset till 72 hours and 7 days
- Secondary Outcome Measures
Name Time Method Secondary outcome will be measured by improvement of organ failure at 72 hours and after 7 days of onset of AP and the difference in the adverse events between the groupsTimepoint: From illness onset till 72 hours and 7 days