The use of autologous platelet-rich-plasma during surgery in patients with gynecological cancer improves wound healing and reduces postoperative pain feeling
Not Applicable
Completed
- Conditions
- Gynecological cancerCancer
- Registration Number
- ISRCTN17395989
- Lead Sponsor
- ational Medical Institute of the Ministry of the Interior and Administration
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 46
Inclusion Criteria
1. Aged > 18 years
2. Diagnosis (or suspicion) of gynecological malignancy (ovarian, endometrial or cervical cancer) with the qualification for surgical treatment by laparotomy
Exclusion Criteria
1. Allergy for analgesics
2. Viral or bacterial local infections, coagulation disorders
3. Body mass index (BMI) > 40 kg/m2
4. Lack of consent for the study enrollment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Wound dehiscence, defined as both complete and partial wound separation (>1 cm long) diagnosed by the clinician during the follow-up period
- Secondary Outcome Measures
Name Time Method 1. Postoperative pain intensity measured using a Visual Analogue Scale (VAS) immediately after the surgery, 6 and 12 hours after the surgery<br>2. Analgesic use after surgery in the early postoperative period measured using data collected in patient medical records, defined as the mean and total number of morphine boluses needed, the number of doses of paracetamol, metamizole and ketoprofen needed per one-day<br>3. Scar quality assessment measured by the Patient and Observer Scar Assessment Scale (POSAS) recorded on days 1, 8, 30 and 90 after surgery by both patient and clinician<br>4. Quality of life assessment after surgery measured using the 12-Item Short Form Survey (SF-12) on days 1, 8, 30 and 90 after surgery