Cardiac Allograft Vasculopathy and Dobutamine Stress Echocardiography / Brain Natriuretic Peptide Coupling

Not Applicable

Completed

• Conditions: Allograft; Vasculopathy
• Interventions: Procedure: Dobutamine stress echocardiography, coronarography, brachial arterial echography

• Registration Number: NCT00384540
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Primary purpose :To early detect cardiac allograft vasculopathy and to identify patients with high risk of cardiac events, by coupling the analysis of the kinetics of the brain natriuretic peptide ( BNP) with that of the left ventricle (LV) during a dobutamine stress echocardiography.

Hypothesis : Plasma BNP elevation and abnormalities of LV kinetic during the ESD, will be associated with the presence of allograft vasculopathy and the arisen of cardiovascular events.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-09
• Study First Submitted: 2006-10-05
• Study First Submitted QC: 2006-10-05
• Study First Posted: 2006-10-06
• Primary Completion: 2015-11-22
• Study Completion: 2016-12-20
• Status Verified: 2017-08
• Last Update Submitted: 2018-07-06
• Last Update Posted: 2018-07-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 53

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Cardiovascular events vs Dobutamine stress echocardiography	Dobutamine stress echocardiography, coronarography, brachial arterial echography	-

Primary Outcome Measures

Name	Time	Method
Cardiovascular events vs Dobutamine stress echocardiography each 2 years	5 years

Secondary Outcome Measures

Name	Time	Method
Flow mediated humeral dilatation each 2 years	5 years

Trial Locations

Locations (1)

Service de Physiologie et d'Explorations Fonctionnelles, Hôpital Civil, Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg, France