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Clinical Trials/ACTRN12615001232527
ACTRN12615001232527
Completed
未知

The prediction of fluid-responsiveness in critically ill patients undergoing pressure support ventilation as assessed by the application of incremental positive intra-thoracic pressures

Federico Longhini MD0 sites40 target enrollmentNovember 10, 2015

Overview

Phase
未知
Intervention
Not specified
Conditions
Not specified
Sponsor
Federico Longhini MD
Enrollment
40
Status
Completed
Last Updated
6 years ago

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
November 10, 2015
End Date
TBD
Last Updated
6 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
Federico Longhini MD

Eligibility Criteria

Inclusion Criteria

  • All patients \> 18 years/old undergoing invasive mechanical ventilation in Pressure Support mode (se with a positive end\-expiratory pressure between 4 and 6 cmH2O and a Pressure Support betweeen 8 and 12 cmH2O), with a clinical need for fluid infusion, i.e. systolic arterial blood pressure \< 90 mmHg or 50 mmHg reduction of values in patients with chronic hypertension, oliguria as defined by a diuresis \< 0\.5 ml/kg/h, need for inotropes, lactate \> 2 mmol/L.

Exclusion Criteria

  • Patients will be excluded if meeting one or more off the following criteria: 1\) cardiac arrhythmia; 2\) atrial fibrillation or flutter; 3\) patients undergoing any form of renal replacement therapy; 4\) valvular defects of moderate to severe grade; 5\) history of congestive cardiac failure; 6\) previous or presence of pneumothorax or emphysema; 7\) patients with Chronic Obstructive Pulmonary Disease (COPD); 8\) patients with kyphoscoliosis; 9\) use of expiratory muscles and 10\) arterial partial pressure to inspired fraction of oxygen (PaO2/FiO2\) ratio \< 200\.

Outcomes

Primary Outcomes

Not specified

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