Effects of a Resistance Training Period on Blood Pressure of Hypertensive Elderlies: Influence of the Polymorphism of the Angiotensin Converting Enzyme

Not Applicable

Completed

• Conditions: Hypertension
• Interventions: Behavioral: Resistance training

• Registration Number: NCT01963507
• Lead Sponsor: Federal University of São Paulo

Brief Summary

The study aimed to evaluate the chronic effects of resistance training on blood pressure and biochemical exams in hypertensive elderlies and the influence of the polymorphism of the angiotensin converting enzyme in these response.

Detailed Description

To investigate the chronic effects of resistance training on blood pressure and biochemical exams in elderly, 135 hypertensive elderlies were divided into 2 groups: trained and control. The trained group was submitted to a resistance training period. Before the 16 weeks ACE gene was genotyped (PCR). Before and after 16 weeks, blood pressure (ambulatory), HDL-cholesterol, Total cholesterol, Glycemia, Triacylglycerol (colorimetric assay) and plasminogen activator inhibition (PAI-1), intercellular adhesion molecule (ICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), Adiponectin, tumor necrosis factor alpha (TNF-alpha), C Reactive Protein, Angiotensin II, Angiotensin Converting Enzyme, Angiotensin 1-7, (ELISA assay) were measured.

Study Timeline

• Study Start: 2010-04
• Primary Completion: 2013-04
• Study Completion: 2013-04
• Status Verified: 2013-10
• Study First Submitted: 2013-10-09
• Study First Submitted QC: 2013-10-11
• Last Update Submitted: 2013-10-11
• Study First Posted: 2013-10-16
• Last Update Posted: 2013-10-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 136

Inclusion Criteria

• Hypertensives
• Age 60 to 85 years
• Nonactive

Exclusion Criteria

• Orthopedic problems or other problem that prevented the exercises
• Change in drug treatment during protocol
• Absence in more than 25% of the exercise sessions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Resistance training	Resistance training	Resistance training performed three times at week for 16 weeks, in 8 exercises for the main muscles, the protocol of 3 sets of 10 repetitions with intensity of 50% of 1 maximum repetition (MR).

Primary Outcome Measures

Name	Time	Method
Blood Pressure	16 weeks	Blood pressure was measured by Ambulatorial Monitoring Blood Pressure before and after 16 weeks of intervention.

Secondary Outcome Measures

Name	Time	Method
Total Cholesterol	16 weeks	Total cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention.
Glycemia	16 weeks	Glycemia was analyzed by colorimetric assay, before and after 16 weeks of intervention.
HDL-cholesterol	16 weeks	HDL-cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention.
Triacylglycerol	16 weeks	Triacylglycerol was analyzed by colorimetric assay, before and after 16 weeks of intervention.
PAI-1	16 weeks	PAI-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.
ICAM-1	16 weeks	ICAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.
VCAM-1	16 weeks	VCAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.
Adiponectin	16 weeks	Adiponectin was analyzed by ELISA assay, before and after 16 weeks of intervention.
TNF alpha	16 weeks	TNF alpha was analyzed by ELISA assay, before and after 16 weeks of intervention.
C Reactive Protein	16 weeks	C Reactive Protein was analyzed by ELISA assay, before and after 16 weeks of intervention.
Angiotensin II	16 weeks	Angiotensin II was analyzed by ELISA assay, before and after 16 weeks of intervention.
Angiotensin Converting Enzyme	16 weeks	Angiotensin Converting Enzyme was analyzed by ELISA assay, before and after 16 weeks of intervention.
Angiotensin 1-7	16 weeks	Angiotensin 1-7 was analyzed by ELISA assay, before and after 16 weeks of intervention.

Trial Locations

Locations (1)

UNIMED; 🇧🇷 Santos, SP, Brazil