Stress-Mediated Widespread Hypersensitivity in People with Irritable Bowel Syndrome

Not Applicable

Completed

• Conditions: Irritable bowel syndrome; Stress; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12616000635460
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-05-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

All participants must speak fluent English and be between the ages of 18-64. IBS participants must have received a diagnosis of IBS from a gastroenterologist.

Exclusion Criteria

Both groups will be screened for the minimum eligibility criteria over the phone in the recruitment phase using the Medical Checklist”. The Medical checklist was composed for this study to rule out any physical or psychiatric variables that may put the participant at risk during the experiment or may confound the results. Due to the nature of the study, the exclusion criteria for each group is extensive:

IBS:

* Any other chronic pain diagnosis
* Any injury or medical condition that may affect ability to sense pain
* A diagnosis of a cardiovascular condition such as hypertension
* Recent acute illness two weeks prior to the study – specifically illnesses affecting the abdomen
* Any other GI diagnosis
* Ingestion of medication two weeks prior participating excluding the oral contraceptive pill
* Pregnancy
* Diagnosis of depression or anxiety or any neuropsychiatric disorder

Healthy Controls:

* Any GI diagnosis
* Family history of GI disorders
* Any chronic pain diagnosis
* Any injury or medical condition that may affect ability to sense pain
* A diagnosis of any cardiovascular diseases such as hypertension.
* Recent acute illness two weeks prior to the study – specifically illnesses affecting the abdomen
* Ingestion of medication two weeks prior participating excluding the oral contraceptive pill
* Pregnancy
* Currently taking psychoactive drugs
* Diagnosis of depression or anxiety or any neuropsychiatric disorder

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of stress on pain sensitivity as assessed by ratings of pain intensity scores during the counter-irritation paradigm on a NRS [ After TSST];Effect of stress on pain sensitivity as assessed by ratings of pain unpleasantness scores during the counter-irritation paradigm on a NRS.[After TSST.];Effect of stress on pain sensitivity as assessed by ratings of stress scores during the counter-irritation paradigm on a NRS.[After TSST]

Secondary Outcome Measures

Name	Time	Method
Difference between groups on heart rate variability during counter-irritation paradigm, assessed using a polar heart rate monitor watch.[Baseline (before TSST) and after TSST.];Difference between groups on heart rate during counter-irritation paradigm, assessed using a polar heart rate monitor watch.[Baseline (before TSST) and after TSST];Mean DASS21 scores for stress for each group[Baseline ];Mean DASS21 scores for anxiety for each group[Baseline ];Mean DASS21 scores for depression for each group[Baseline];Mean pain Catastrophizing scores for each group[Baseline]