Acute Sodium Bicarbonate Supplementation in Athletes
- Conditions
- SportSupplementation
- Interventions
- Dietary Supplement: Sodium bicarbonate supplementationDietary Supplement: Placebo treatment
- Registration Number
- NCT03810404
- Lead Sponsor
- Poznan University of Physical Education
- Brief Summary
The purpose of this study is to verify the effect of acute sodium bicarbonate (SB) and placebo (PLA) supplementation on buffering potential kinetics, physical capacity, discipline-specific performance as well as concentration of diagnostically significant blood biochemical indices in athletes, in a randomised, double-blind, placebo-controlled crossover trial.
- Detailed Description
Effective muscle work is conditioned by maintaining the proper range of muscles pH, regulated by buffering systems, in which the main role is played by bicarbonates (HCO3-). For this reason, sodium bicarbonate (SB) is often proposed as an ergogenic agent, especially during high-intensity efforts. Until now the major limitation to SB supplementation has been the gastrointestinal (GI) side effects. There is also a lack of data of the individual SB-induced changes of buffering potential kinetics and its actual connection with physical capacity and discipline-specific performance. Therefore, this study aims to examine the effect of acute, different-dose SB ingestion on buffering potential kinetics, physical capacity, discipline-specific performance as well as changes of diagnostically significant blood biochemical indices concentration in athletes, in a randomised, double-blind, placebo-controlled crossover trial.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 50
- written consent to participate,
- a current medical clearance to practice sports,
- training experience: at least 2 years,
- minimum of 4 workout sessions (in the discipline covered by the study) a week.
- current injury,
- any health-related contraindication,
- declared general feeling of being unwell,
- unwilling to follow the study protocol.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Sodium bicarbonate supplementation Sodium bicarbonate supplementation Group taking oral SB supplementation in a different-dose regimen. Placebo treatment Placebo treatment Group taking oral supplementation with placebo (NaCl).
- Primary Outcome Measures
Name Time Method Changes in anaerobic capacity after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation The Wingate cycling test carried out at baseline, and after SB and PLA supplementation
Changes of bicarbonate concentration in blood after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation Bicarbonate (HCO3-) \[mmol/L\] concentration analysis in blood carried out at baseline, and after SB and PLA supplementation
Changes in discipline-specific exercise capacity after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation The discipline-specific exercise capacity tests carried out at baseline, and after SB and PLA supplementation
Changes of base excess concentration in blood after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation Base excess \[mmol/L\] concentration analysis in blood carried out at baseline, and after SB and PLA supplementation
- Secondary Outcome Measures
Name Time Method Changes of pH in blood after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation Blood pH (pH units) analysis carried out at baseline, and after SB and PLA supplementation
Changes of lactate concentration in blood after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation Lactate \[mmol/L\] concentration analysis carried out at baseline, and after SB and PLA supplementation
Changes in blood glucose concentration after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation Glucose \[g/dl\] concentration analysis carried out at baseline, and after SB and PLA supplementation
Changes of lactate dehydrogenase activity in blood after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation Lactate dehydrogenase \[U/L\] activity analysis carried out at baseline, and after SB and PLA supplementation
Changes of creatine kinase activity in blood after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation Creatine kinase \[U/L\] activity analysis carried out at baseline, and after SB and PLA supplementation
Changes of pyruvate concentration in blood after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation Pyruvate \[mmol/L\] concentration analysis carried out at baseline, and after SB and PLA supplementation
Changes in hemoglobin concentration after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation Hemoglobin (Hb) \[g/dl\] concentration analysis carried out at baseline, and after SB and PLA supplementation
Changes of blood cells concentration in blood after sodium bicarbonate supplementation and placebo treatment Baseline and during 1 day of acute SB and PLA supplementation Blood cells \[mln/mm³\] concentration analysis carried out at baseline, and after SB and PLA supplementation
Trial Locations
- Locations (1)
Department of Sports Dietetics, Poznan University of Physical Education
🇵🇱Poznań, Poland