LEFT VENTRICULAR FAILURE IN PATIENTS OF ACUTE EXACERBATION OF COPD

Not yet recruiting

• Conditions: Chronic obstructive pulmonary disease with (acute) exacerbation,

• Registration Number: CTRI/2020/08/027139
• Lead Sponsor: Maulana Azad Medical College

Brief Summary

Purpose of trial - To evaluate prevalence of left ventricular systolic dysfunction in patients with acute exacerbation of COPD

Objectives -



Primary Objective-To evaluate the prevalence of left ventricular systolic dysfunction in patients with acute exacerbation of COPD



Secondary Objective - To determine correlation between NTpro BNP levels and left ventricular systolic dysfunction in patients with acute exacerbation of COPD



Some Major findings and references-



In a research study conducted by Winther et al. evaluating the diagnostic and prognostic significance of NT pro BNP in acute exacerbation of COPD and heart failure it was found to be a good marker to separate dyspnoea due to acute heart failure and not due to heart failure.



A study by Chang et al. analysed cardiac biomarkers in predicting mortality in acute exacerbation of COPD



In a study by Abroug et al. showed 31 % patients admitted in ICU for severe AE COPD had associated left heart dysfunction. NT pro BNP levels performed better to rule out than to rule in AECOPD with left dysfunction.An NT proBNp level of 1000pg/ml or less was the optimal cutoff to rule out an association of LV dysfunction with sensitivity of 94 % negative predictive value 94% and negative likelihood ratio of 0.08.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-07-29
• Study Start: 2020-08-29

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients with age 18 years or more with acute exacerbation of chronic obstructive pulmonary disease and ability to undergo echocardiography.

Exclusion Criteria

Pulmonary embolism Pneumonia Pneumothorax Renal Dysfunction Acute coronary event Valvular Heart Disease Hepatic Dysfunction Known case of Dilated Cardiomyopathy.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate the prevalence of ventricular systolic dysfunction in patients of acute exacerbation of chronic obstructive pulmonary disease	Less than or equal to one year

Secondary Outcome Measures

Name	Time	Method
To determine the correlation between NTproBNP levels and Left ventricular systolic dysfunction in acute exacerbation of COPD	Less than or equal to one year

Trial Locations

Locations (1)

Lok Nayak Hospital; 🇮🇳 Delhi, DELHI, India

Lok Nayak Hospital

🇮🇳Delhi, DELHI, India

Prachi Bagarhatta

Principal investigator

8130143634

bagarhattaprachi@gmail.com