IVF Hyper-responders: Oocyte Vitrification Compared With Embryo Freezing

Not Applicable

Completed

• Conditions: Infertility

• Registration Number: NCT02026193
• Lead Sponsor: Rambam Health Care Campus

Brief Summary

The chances to achieve pregnancy after retrieving \>15 oocytes are not good, probably because of bad effect on the endometrium (uterine inner lining). Therefore, in most such cases the investigators prefer to freeze all embryos, and transfer in a thaw cycle. With the introduction of oocyte vitrification (very fast cooling) technology, a new option emerged: to freeze un-fertilized eggs, to be fertilized and used later in a thaw cycle.

The purpose of this study is to compare the outcome of these two approaches.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-12-30
• Study First Submitted QC: 2013-12-31
• Study Start: 2014-01
• Study First Posted: 2014-01-01
• Primary Completion: 2014-11
• Study Completion: 2015-04
• Results First Submitted: 2015-04-29
• Status Verified: 2015-05
• Results First Submitted QC: 2015-05-20
• Last Update Submitted: 2015-05-20
• Results First Posted: 2015-06-08
• Last Update Posted: 2015-06-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 11

Inclusion Criteria

• IVF patients
• ovulation trigger with Decapeptyl 0.2 mg because of ovarian hyper-response: E2 on trigger day .12,000 pmol/l and/or >15 oocytes.
• Normal uterus

Exclusion Criteria

• <20% fertilization rate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Fetal Heart Activity 1 Month Post Embryo Transfer	1 month after embryo transfer	Fetal heart activity as demonsrated by vaginal ultrasound 1 month post embryo transfer

Trial Locations

Locations (1)

IVF Unit, Rambam medical Center; 🇮🇱 Haifa, Israel