Effect of adjusting the combination of budesonide/formoterol on asthma management for 24 weeks
- Conditions
- asthma
- Registration Number
- JPRN-UMIN000009599
- Lead Sponsor
- Dokkyo Medical University
- Brief Summary
Background The combination of budesonide + formoterol (BFC) offers the advantages of dose adjustment in a single inhaler according to asthma symptoms. We analyzed the relationship between asthma symptoms in terms of peak expiratory flow (PEF) and dose adjustment by the patient. Methods Twenty-eight patients with asthma who used BFC for alleviation of their symptoms (12 men, 16 women; 60 years old) were instructed that the inhaled BFC dose could be increased to a maximum of 8 inhalations per day according to symptom severity. Patients measured and recorded PEF every morning and evening in their asthma diary along with their symptoms and the dose of drugs taken. Results Sixteen of the 28 patients increased their dose for asthma symptoms. The time to recovery from the asthma symptoms was significantly shorter when cough was the only symptom present compared with dyspnea or wheeze (1.4 vs. 5.3 or 6.6 days, p<0.05) and when they had only one symptom compared with two or three symptoms (1.3 vs. 5.7 or 10.5, p<0.01). The relationship between PEF (% of personal best) when the dose was increased (Y) and the days for the increased dose to achieve a PEF greater than PEF in the symptom-free state (X) was determined to be Y=-0.591X+89.2 (r2=0.299, p<0.001).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Not provided
Patients who need the corticosteroid excepting the inhale corticosteroid. Patients with other respiratory diseases, malignant diseases, pregnancy and/or lactation.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method asthmatic symptpms and peak expiratory flow rate
- Secondary Outcome Measures
Name Time Method