Comparison of Acceleromyography (AMG) and Mechanomyography (MMG) for Establishing Potency of Neuromuscular Blocking Agents
Phase 4
Completed
- Conditions
- Neuromuscular Blockade
- Interventions
- Device: TOF-Watch SX (Acceleromyography)
- Registration Number
- NCT00660413
- Lead Sponsor
- Rigshospitalet, Denmark
- Brief Summary
The purpose of this study was to compare two methods for neuromuscular monitoring, acceleromyography and mechanomyography for establishing the dose-response relationship and the potency of a neuromuscular blocking agent using rocuronium as an example. We hypothesized that there would be no significant difference between potencies estimated using acceleromyography and mechanomyography.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- ASA I-III
- Ideal weight +/-20%
- Both arms available for neuromuscular monitoring
- Surgery in supine position
- Participated surgery time more than 30 min
Exclusion Criteria
- Pregnant and breast-feeding women
- Patients with known illness or use of medications known to influence the neuromuscular transmission
- Known significant renal or hepatic dysfunction
- Allergy to medications used in the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description AMG TOF-Watch SX (Acceleromyography) Acceleromygraphy monitoring MMG TOF-Watch SX (Acceleromyography) Mechanomyography monitoring
- Primary Outcome Measures
Name Time Method Comparison of ED50 with the two methods
- Secondary Outcome Measures
Name Time Method Comparison of ED95 with the two methods
Trial Locations
- Locations (1)
Rigshospitalet
🇩🇰Copenhagen, Østerbro, Denmark