Greater Occipital Nerve Blockade for the Treatment of Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study
Overview
- Phase
- Phase 4
- Intervention
- Betamethasone and local anesthetic
- Conditions
- Chronic Migraine
- Sponsor
- Jakob Møller Hansen, MD.
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- Number of migraine days
- Last Updated
- 10 years ago
Overview
Brief Summary
Infiltration of the greater occipital nerve (GON) with local anaesthetics and corticosteroids is a treatment option for cluster headache. Corticosteroids may be helpful in reducing the pain intensity and frequency in chronic migrtaine. This RCT is set up to assess efficacy and safety of sub-occipital steroid injections with local anesthetic in patients with chronic migraine.
Detailed Description
Infiltration of the greater occipital nerve (GON) with local anaesthetics and corticosteroids is a treatment option for cluster headache. In general, there is a marked paucity of evidence concerning GON blocks in migraine. Corticosteroids may be helpful in reducing the pain intensity and frequency in these patients. This is an RCT to assess efficacy and safety of sub-occipital steroid injections with local anesthetic in patients with chronic migraine.
Investigators
Jakob Møller Hansen, MD.
MD, PhD
Danish Headache Center
Eligibility Criteria
Inclusion Criteria
- •Chronic migraine
Exclusion Criteria
- •Medication overuse headache
Arms & Interventions
Active
Betamethasone and local anesthetic.
Intervention: Betamethasone and local anesthetic
Placebo
Saline with local anesthetic.
Intervention: Betamethasone and local anesthetic
Outcomes
Primary Outcomes
Number of migraine days
Time Frame: 8 weeks
Number of days fulfilling the ICHD criteria for migraine
Secondary Outcomes
- Responder rate(8 weeks)
- Number of days with severe headache days(8 weeks)
- Medication use(8 weeks)
- Number of migraine attacks(8 weeks)