Greater Occipital Nerve Blockade for the Treatment of Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Number of migraine days
研究概览
简要总结
Infiltration of the greater occipital nerve (GON) with local anaesthetics and corticosteroids is a treatment option for cluster headache. Corticosteroids may be helpful in reducing the pain intensity and frequency in chronic migrtaine. This RCT is set up to assess efficacy and safety of sub-occipital steroid injections with local anesthetic in patients with chronic migraine.
详细描述
Infiltration of the greater occipital nerve (GON) with local anaesthetics and corticosteroids is a treatment option for cluster headache. In general, there is a marked paucity of evidence concerning GON blocks in migraine. Corticosteroids may be helpful in reducing the pain intensity and frequency in these patients. This is an RCT to assess efficacy and safety of sub-occipital steroid injections with local anesthetic in patients with chronic migraine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic migraine
排除标准
- •Medication overuse headache
研究组 & 干预措施
Active
Betamethasone and local anesthetic.
干预措施: Betamethasone and local anesthetic (Drug)
Placebo
Saline with local anesthetic.
干预措施: Betamethasone and local anesthetic (Drug)
结局指标
主要结局
Number of migraine days
时间窗: 8 weeks
Number of days fulfilling the ICHD criteria for migraine
次要结局
- Responder rate(8 weeks)
- Number of days with severe headache days(8 weeks)
- Medication use(8 weeks)
- Number of migraine attacks(8 weeks)
研究者
Jakob Møller Hansen, MD.
MD, PhD
Danish Headache Center