Influence of Epidural Analgesia on Natural Killer Cell (NK) Activity After Colonic Cancer Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Count of live and dead target erythroleukemic cells
研究概览
简要总结
Regional anesthesia may decrease the release of endogenous opioids, increase Natural Killer cell (NK) function and decrease development of metastasis. The recent analysis of the Cancer Registry has noted an improved 5-year survival in patients who received epidural analgesia during surgery for colorectal carcinoma.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing colonic cancer surgery
排除标准
- •Patients with poor physical status Patients needed emergency surgery Coagulopathic disorders with international normalized ratio (INR) level more than 1.4 Thrombocytopenia with platelets count less 100000 per mcl Allergic reaction to local anesthetics in patient history Failure to performing the epidural analgesia from another cause Preoperative immunomodulating treatment Recent history of chemotherapy or radiation therapy
研究组 & 干预措施
General Anesthesia
Patients receiving general anesthesia with Fentanyl,Propofol, Isoflurane and Nitrous Oxide only during colonic cancer surgery
干预措施: Fentanyl (Drug)
General Anesthesia
Patients receiving general anesthesia with Fentanyl,Propofol, Isoflurane and Nitrous Oxide only during colonic cancer surgery
干预措施: Propofol (Drug)
General Anesthesia
Patients receiving general anesthesia with Fentanyl,Propofol, Isoflurane and Nitrous Oxide only during colonic cancer surgery
干预措施: Isoflurane (Drug)
General Anesthesia
Patients receiving general anesthesia with Fentanyl,Propofol, Isoflurane and Nitrous Oxide only during colonic cancer surgery
干预措施: Nitrous Oxide (Drug)
Combined anesthesia
Patients receiving general anesthesia and epidural analgesia with Ropivacaine during colonic cancer surgery
干预措施: Ropivacaine (Drug)
Combined anesthesia
Patients receiving general anesthesia and epidural analgesia with Ropivacaine during colonic cancer surgery
干预措施: Fentanyl (Drug)
Combined anesthesia
Patients receiving general anesthesia and epidural analgesia with Ropivacaine during colonic cancer surgery
干预措施: Propofol (Drug)
Combined anesthesia
Patients receiving general anesthesia and epidural analgesia with Ropivacaine during colonic cancer surgery
干预措施: Isoflurane (Drug)
Combined anesthesia
Patients receiving general anesthesia and epidural analgesia with Ropivacaine during colonic cancer surgery
干预措施: Nitrous Oxide (Drug)
结局指标
主要结局
Count of live and dead target erythroleukemic cells
时间窗: 72 hours
All clinical and laboratory parameters from blood samples taken before and after the operation will be compared between the two groups of patients. The nominal data comparison will be performed by ANOVA test, and the nonparametric data will be performed by Mann-Whitney test and interquartile ranges (IQR) for non-normally distributed data.
Plasma concentration of cytokines
时间窗: 72 hours
All clinical and laboratory parameters from blood samples taken before and after the operation will be compared between the two groups of patients. The nominal data comparison will be performed by ANOVA test, and the nonparametric data will be performed by Mann-Whitney test and interquartile ranges (IQR) for non-normally distributed data.
次要结局
未报告次要终点