Stress Reduction and Anxiety: Effects on the Function and Structure of the Brain

Not Applicable

Completed

• Conditions: Generalized Anxiety Disorder
• Interventions: Behavioral: Stress Reduction Intervention; Behavioral: Active Control intervention

• Registration Number: NCT01128309
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

The aim of the study is to test whether Generalized Anxiety Disorder (GAD) patients that participate in a Stress Reduction Intervention show a brain activation pattern (assessed by MRI) indicative of improved emotion regulation compared to an active control intervention.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05
• Study First Submitted: 2010-05-19
• Study First Submitted QC: 2010-05-20
• Study First Posted: 2010-05-21
• Primary Completion: 2011-04
• Study Completion: 2011-04
• Status Verified: 2012-05
• Last Update Submitted: 2012-05-04
• Last Update Posted: 2012-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• participation in the study 'Stress Reduction Techniques and Anxiety: Therapeutic and Neuroendocrine Effects" by Dr. Elizabeth Hoge

Exclusion Criteria

• metallic implants
• left handed
• epileptic seizures
• head trauma
• weight over 350 pounds
• claustrophobia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Stress Reduction Intervention	Stress Reduction Intervention	Stress Reduction Intervention
Active Control Condition	Active Control intervention	-

Primary Outcome Measures

Name	Time	Method
brain activation and structure as assessed by MRI	Day 2 (within two weeks after the intervention)	BOLD functional MRI and structural MRI

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Charlestown, Massachusetts, United States