Development of Clinical Assessment Technique Using Multi-radiotracer PET/MR in Prostate Cancer

Brief Summary

Detailed Description

To establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer * Recruiting 30 patients with prostate cancer ahead to radical prostatectomy * PET/MR using 18F-choline with dedicated prostate MRI in all patients * PET/MR using 18fluoride(F)-fluorodeoxyglucose(FDG)in all patients after 2-7 days * PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR * outcome assessment: comparison of scan time, image quality, tumor detection rate, standardized uptake values of lesions * establishing optimal imaging technique for prostate PET/MR To establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer * comparison of findings on PET/MR, MRI and PET/CT with pathological mapping after radical prostatectomy * outcome assessment: accuracy of PET/MR for localization and staging of prostate cancer compared with MRI only and PET/CT only To establish the imaging biomarker using PET/MR for early detection of recurrent prostate cancer * Recruiting 15 patients with recurrent prostate cancer treated by surgery, hormone, or radiation therapy * Recruiting 15 patients with treated prostate cancer without recurrence * PET/MR using 18F-choline with dedicated prostate MRI in all patients * PET/MR using 18F-FDG in all patients after 2-7 days * PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR * comparison of findings on PET/MR, MRI, and PET/CT with clinical data in two patient groups with or without recurrent prostate cancer * outcome assessment: accuracy of PET/MR for early detection and localization of recurrent prostate cancer compared with MRI only and PET/CT only

Primary Outcomes

Secondary Outcomes

• accuracy of early detection and localization of recurrent prostate cancer(1 week after PET/MR imaging)