Development of Clinical Assessment Technique Using Multi-radiotracer PET/MR in Prostate Cancer
- Conditions
- Prostate Cancer RecurrentStage II Prostate CarcinomaStage III Prostate Carcinoma
- Interventions
- Device: PET/MR
- Registration Number
- NCT01938339
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
To development of clinical assessment technique using multi-radiotracer positron emission tomography/magnetic resonance (PET/MR) in prostate cancer
* to establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer
* to establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer and early detection of recurrent prostate cancer
- Detailed Description
To establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer
* Recruiting 30 patients with prostate cancer ahead to radical prostatectomy
* PET/MR using 18F-choline with dedicated prostate MRI in all patients
* PET/MR using 18fluoride(F)-fluorodeoxyglucose(FDG)in all patients after 2-7 days
* PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR
* outcome assessment: comparison of scan time, image quality, tumor detection rate, standardized uptake values of lesions
* establishing optimal imaging technique for prostate PET/MR
To establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer
* comparison of findings on PET/MR, MRI and PET/CT with pathological mapping after radical prostatectomy
* outcome assessment: accuracy of PET/MR for localization and staging of prostate cancer compared with MRI only and PET/CT only
To establish the imaging biomarker using PET/MR for early detection of recurrent prostate cancer
* Recruiting 15 patients with recurrent prostate cancer treated by surgery, hormone, or radiation therapy
* Recruiting 15 patients with treated prostate cancer without recurrence
* PET/MR using 18F-choline with dedicated prostate MRI in all patients
* PET/MR using 18F-FDG in all patients after 2-7 days
* PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR
* comparison of findings on PET/MR, MRI, and PET/CT with clinical data in two patient groups with or without recurrent prostate cancer
* outcome assessment: accuracy of PET/MR for early detection and localization of recurrent prostate cancer compared with MRI only and PET/CT only
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 60
- patient with prostate cancer before treatment
- patient with prostate cancer treated
- patient with prostate cancer recurrent
- patient with contraindication for MRI
- Patient with severe renal impairment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description PET/MR PET/MR Multi-radiotracer PET/MR will be performed to compare the accuracy of tumor detection in patient with primary prostate cancer
- Primary Outcome Measures
Name Time Method accuracy of PET/MR predicting localization and staging of prostate cancer 1 week after radical prostatectomy analysis of accuracy of PET/MR predicting localization and staging of prostate cancer by comparison of PET/MR findings with pathological mapping images after radical prostatectomy
- Secondary Outcome Measures
Name Time Method accuracy of early detection and localization of recurrent prostate cancer 1 week after PET/MR imaging accuracy of PET/MR for early detection and localization of recurrence by comparison of PET/MR findings with clinical data in two groups of patients with or without recurrent prostate cancer
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of