Investigating the role of rTMS in the treatment of chronic depressio

Phase 4

Recruiting

• Conditions: depression; major depressive disorder; 10027946

• Registration Number: NL-OMON43899
• Lead Sponsor: Psychiatrie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

• Males and females above 18 years of age
• First or recurrent unipolar major depressive disorder without psychotic symptoms (DSM-IV), with a chronic course during the last two years
• Treatment resistance for at least two antidepressants treatment and a form of psychotherapy.

Exclusion Criteria

Presence of a current or past relevant somatic or neurological disorder
A comorbid diagnosis of bipolar disorder, schizophrenia or substance dependence disorders.;With regard to transcranial brain stimulation
• Epilepsy, convulsion or seizure (TMS)
• Serious head trauma or brain surgery
• Large or ferromagnetic metal parts in the head (except for a dental wire)
• Implanted cardiac pacemaker or neurostimulator
• Pregnancy
With regard to other experimental techniques
MRI-related exclusion criteria like claustrophobia, metal in body, pacemaker, pregnancy, etc.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint is the change in depressive symptoms between both groups after<br /><br>rTMS treatment. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoint is the change in depressive symptoms after 5 weeks and<br /><br>routine -outcome monitoring (ROM) parameters.</p><br>