Variations of Portal Flow During the Respiratory Cycle in Healthy Volunteers

Not Applicable

Active, not recruiting

• Conditions: Respiratory Amplitude; MRI; Echo Planar Imaging; Portal Blood Flow

• Registration Number: NCT04782531
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

The analysis of portal vein blood flow is important when assessing the severity and progression of liver disease. It is important to understand normal liver regulation in order to appreciate the evaluation of the effect of treatment during the disease progression. The influence of respiration on hepatic hemodynamics is still poorly understood, although some studies have shown a significant impact. The purpose of this project is to quantify the blood flow variations in the portal vein at different positions during the respiratory cycle by using a fast MRI sequence and an Echo Planar (EPI) acquisition.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-01
• Study First Submitted: 2021-03-02
• Study First Submitted QC: 2021-03-02
• Study First Posted: 2021-03-04
• Primary Completion: 2023-03-01
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-09
• Last Update Posted: 2024-04-10
• Study Completion: 2024-06

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Age ≥ 18 ans
• Healthy subject without history of hepatic disease

Exclusion Criteria

• history of hepatic pathology
• pregnant woman
• claustrophobia
• major obesity
• any contraindication to MRI exam

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
flow rates variation between the fast sequence averaged values and the standard sequence	30 minutes	flow rates variation between the fast sequence averaged values and the standard sequence during free breathing.

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France