Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes
Not Applicable
Completed
- Conditions
- Type 2 Diabetes MellitusMetabolic and Endocrine - Diabetes
- Registration Number
- ACTRN12608000217303
- Lead Sponsor
- niversity of the West Indies
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 231
Inclusion Criteria
Type 2 diabetes mellitus subjects without malnutrition or severe complications of the disease (cardiovascular, renal, visual and cerebral), male or female, duration of the disease between 1-10 years, good psychological condition, non-smoker and non-alcoholic. Patient given written consent after provided with sufficient information about participation in the trial.
Exclusion Criteria
Pregnant, high blood pressure, psychiatric disorders, severe heart failure or other acutely life-threatened conditions, severe chronic inflammatory disease, less than 40 years old, renal disease, duration of type 2 diabetes greater than 10 years, newly diagnosed persons with type diabetes.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The fasting blood glucose concentration for each group was determined by using the Reflolux S type 1172115 glucometers. Total cholesterol, triglyceride and high density lipoprotein (HDL) were determined by enzymatic methods. High density lipoprotein was measured after precipitating very low density lipoprotein (VLDL) and low density lipoprotein (LDL) cholesterol in the presence of magnesium ions. The LDL fraction was calculated by the Friedwald formula. <br>Changes in fasting blood glucose, total cholesterol, low density lipoprotein and high density lipoprotein cholesterol from baseline to 6 months.[At baseline, 3 and 6 months]
- Secondary Outcome Measures
Name Time Method Malondialdehyde concentration in the serum was measured spectrophotometrically. Protein oxidation is based on the detection of the carbonyl group that appears as a result of the oxidation of lateral chains of certain amino acids. Plasma carbonyl group levels were evaluated following the 2,4-dinitrophenylhydrazine (2,4-DNP) assay. The superoxide dismutase activity was determined by inhibition of pyrogallin and catalase activity was measured by ultraviolet method, based on the transformation of hydrogen peroxide.<br>Changes in Malondialdehyde, protein oxidation, super oxide and catalase activities from baseline to 6 months.[At baseline, 3 and 6 months]