Exercise and fatty liver with moderate alcohol consumptio

Completed

• Conditions: Topic: Hepatology; Subtopic: Hepatology; Disease: All Hepatology; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN90597099
• Lead Sponsor: ewcastle upon Tyne Hospitals NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-22
• Last Update Posted: 3 July 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

1. Fatty liver
2. Moderate alcohol consumption (18-42 units/week for men; 11-28 units/week for women)
3. Sedentary
4. The person's weight needs to be stable prior to entering the study
5. Aged over 18
6. Understanding of English
Target Gender: Male & Female; Upper Age Limit 75 years; Lower Age Limit 18 years

Exclusion Criteria

1. In vivo ferrous material preventing MRI examination
2. Glitazones (rosiglitazone and pioglitazone) are not permitted. All other insulin sensitising medication must be stable for previous 6 months
3. HBA1c >9.5
4. Current weight loss or change in drinking habits
5. Vitamin E (>400UI/day), PUFAs (>2g/day) and Ursodeoxycholic acid are not permitted
6. Currently taking drugs that can induce Steatosis/steatohepatitis: corticosteroids (parenteral administration only), amiodarone (Cordarone), Tamoxifen (Nolvadex), methotrexate (Rheumatrex, Trexall)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
iver lipids, abdominal fat content, insulin sensitivity, lipid oxidation and inflammation.; Timepoint(s): 12 weeks