Ketamine and Internalizing Disorders

Phase 1

Recruiting

• Conditions: Depression; Post-Traumatic Stress Disorder; Obsessive-Compulsive Disorder; Phobic Disorders; Mental Health - Depression; Mental Health - Anxiety; Mental Health - Other mental health disorders

• Registration Number: ACTRN12619000311156
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-02-28
• Last Update Posted: 12 July 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

•Capable of understanding and signing an informed consent
•diagnosed with one of the following DSM-5 diagnoses:
-post-traumatic stress disorder (PTSD) with a CAPS score >60;
-obsessive-compulsive disorder (OCD) with a YBOCS score >26;
-major depressive disorder (MDD) with a MADRS score >20;
-phobic state with FQ18 score >6
•Patients with PTSD, OCD or phobic state must not have MADRS scores >20 at screening.
•Patients must have had an inadequate response to prior treatment i.e. have not responded to at least two adequate trials of relevant medication and at least one trial of relevant psychotherapy.

Exclusion Criteria

•evidence of severe acute or chronic medical disorders,
•past or current diagnoses of schizophrenia, bipolar disorder, or current psychotic symptoms
•female patients who are pregnant or lactating
•drug use or dependence in the last 6 months
•current significant suicidal ideation
•prior history of seizures; susceptibility to photosensitivity; or a history of allergic skin reactions

Study & Design

• Study Type: Interventional
• Study Design: Not specified